2023
DOI: 10.1186/s12944-023-01847-7
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Adipose tissue dysfunction serum markers are associated with high density lipoprotein size and glycation in the early stages of type 2 diabetes

Abstract: Background High-density lipoproteins (HDLs) have antiatherogenic properties related to their chemical structure. Adipose tissue (AT) influences HDL reverse cholesterol transport and plasma HDL cholesterol levels. However, whether AT dysfunction affects HDL subpopulations and their glycation in early type 2 diabetes (T2D) is still unknown. Objective To investigate the association of inflammation and AT dysfunction serum markers with the size and gly… Show more

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Cited by 4 publications
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“…Abnormalities in HDL structure impair its function resulting in alterations in glucose and lipid metabolism, protein glycation, lipid oxidation, and inflammation. The diverse biological activities of HDL particles are closely associated with their varied functions in vivo, and these are pertinent to the pathophysiology of hyperglycaemia, inflammation, dyslipidemia, and vascular dysfunction in diabetes [ 10 , 11 ]. They contribute to the maintenance and repair of endothelial tissues and regulate aspects of the innate and adaptive immune system responses.…”
Section: Introductionmentioning
confidence: 99%
“…Abnormalities in HDL structure impair its function resulting in alterations in glucose and lipid metabolism, protein glycation, lipid oxidation, and inflammation. The diverse biological activities of HDL particles are closely associated with their varied functions in vivo, and these are pertinent to the pathophysiology of hyperglycaemia, inflammation, dyslipidemia, and vascular dysfunction in diabetes [ 10 , 11 ]. They contribute to the maintenance and repair of endothelial tissues and regulate aspects of the innate and adaptive immune system responses.…”
Section: Introductionmentioning
confidence: 99%