Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity

Festa, Joseph; AlZaim, Ibrahim; Kalucka, Joanna

doi:10.1016/j.gde.2023.102055

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Nevertheless, the cellular composition of WAT extends beyond adipocytes. WAT encompasses various non-adipocyte cell types that include: Endothelial cells: Form the lining of blood vessels within AT, playing a crucial role in nutrient transport, angiogenesis, and tissue oxygenation [ 16 ]. Blood cells: Include various types of cells involved in the immune response and the transport of oxygen and nutrients [ 17 ].…”

Section: Types and Composition Of Adipose Tissuementioning

confidence: 99%

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Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition

Lopez-Yus,

Hörndler,

Borlan

et al. 2024

Cells

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Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses. It comprises mainly two types: white adipose tissue (WAT) for energy storage and brown adipose tissue (BAT) for thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, is involved in various metabolic activities, notably lipogenesis and lipolysis, critical for maintaining energy homeostasis. It also functions as an endocrine organ, secreting adipokines that influence metabolic, inflammatory, and immune processes. However, dysfunction in WAT, especially related to obesity, leads to metabolic disturbances, including the inability to properly store excess lipids, resulting in ectopic fat deposition in organs like the liver, contributing to non-alcoholic fatty liver disease (NAFLD). This narrative review delves into the multifaceted roles of WAT, its composition, metabolic functions, and the pathophysiology of WAT dysfunction. It also explores diagnostic approaches for adipose-related disorders, emphasizing the importance of accurately assessing AT distribution and understanding the complex relationships between fat compartments and metabolic health. Furthermore, it discusses various therapeutic strategies, including innovative therapeutics like adipose-derived mesenchymal stem cells (ADMSCs)-based treatments and gene therapy, highlighting the potential of precision medicine in targeting obesity and its associated complications.

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Section: Types and Composition Of Adipose Tissuementioning

confidence: 99%

“…Endothelial cells: Form the lining of blood vessels within AT, playing a crucial role in nutrient transport, angiogenesis, and tissue oxygenation [ 16 ].…”

Section: Types and Composition Of Adipose Tissuementioning

confidence: 99%