Adipose tissue fatty acids and insulin sensitivity in elderly men

Iggman, David; Ärnlöv, Johan; Vessby, Bengt; Cederholm, Tommy; Sjögren, Per; Risérus, Ulf

doi:10.1007/s00125-010-1669-0

Cited by 78 publications

(76 citation statements)

References 40 publications

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“…In this study, total SFAs in serum significantly decreased with the hypocaloric diet, among them palmitic acid (C16:0) and stearic acid (C18:0), which have been previously related with the incidence of Type 2 diabetes [19,24]. Also, total SFAs may increase CVD risk by raising levels of LDL-c and total cholesterol [13].…”

Section: Discusionsupporting

confidence: 49%

Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention

et al. 2014

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3 AbstractThe application of metabolomics in nutritional research may be a useful tool to analyse and predict the response to a dietary intervention. The aim of this study was to examine metabolic changes in serum samples following exposure to an energy-restricted diet (-15% of daily energy requirements) over a period of 8 weeks in overweight and obese older adults (n=22) using a GC/MS metabolomic approach. After the 8 weeks, there were significant reductions in weight (7%) and metabolic improvement (glucose and lipid profile). Metabolomic analysis found that total saturated fatty acids (SFAs), including palmitic acid (C16:0) and stearic acid (C18:0) and monounsaturated fatty acids (MUFAs) were significantly decreased after the 8 week intervention.Furthermore, palmitoleic acid (C16:1) was found to be a negative predictor of change in body fat loss. Both the total ω-6 and ω-3 polyunsaturated fatty acids (PUFAs) significantly decreased although the overall total amounts of PUFAs did not. The branched chain amino acid (BCAA) isoleucine significantly decreased in the serum samples after the intervention. In conclusion, this study demonstrated that the weight loss intervention based on a hypocaloric diet identified changes in the metabolic profiles of serum in overweight and obese older adults, with a reduction in anthropometric and biochemical parameters also found.

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Section: Discusionsupporting

confidence: 49%

Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention

et al. 2014

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“…For instance, a higher concentration of circulating 14 and 16 carbon fatty acids may expose tissues to greater lipotoxicity, for instance from palmitic acid (16:0), which is well-known to have harmful effects on tissues (46,47). Our study extends these findings by showing that TGFA with 14 to 16 carbons clustered together and this pattern strongly associated with lower insulin sensitivity.…”

Section: Discussionsupporting

confidence: 75%

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes

Johnston

Liu

Retnakaran

et al. 2018

Journal of Lipid Research

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“…In these studies, only elderly white men with a mean age of 71 were included, which limits external validity (81,106).…”

Section: Diabetes and Insulin Resistancementioning

confidence: 99%

The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease

Frigolet

Gutiérrez-Aguilar

2017

Advances in Nutrition

197

143

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The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Although trans-palmitoleate is also synthesized in humans, it is mainly found as an exogenous source in ruminant fat and dairy products. Recently, palmitoleate was considered to be a lipokine based on evidence demonstrating its release from adipose tissue and its metabolic effects on distant organs. After this finding, research has been performed to determine whether palmitoleate has beneficial effects on metabolism and to elucidate the underlying mechanisms. Thus, the aim of this work was to review the current status of knowledge about palmitoleate, its metabolism, and its influence on metabolic abnormalities. Results have shown mixed cardiovascular effects, direct or inverse correlations with obesity, and hepatosteatosis, but a significant amelioration or prevention of insulin resistance and diabetes. Finally, the induction of palmitoleate release from adipose tissue, dietary intake, and its supplementation are all interventions with a potential impact on certain metabolic diseases. Adv Nutr 2017;8(Suppl):173S-81S.

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Adipose tissue fatty acids and insulin sensitivity in elderly men

Abstract: Aims/hypothesis Dietary

Cited by 78 publications

References 40 publications

Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention

Metabolomics identifies changes in fatty acid and amino acid profiles in serum of overweight older adults following a weight loss intervention

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes

The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease

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