2007
DOI: 10.2337/db06-0911
|View full text |Cite
|
Sign up to set email alerts
|

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

Abstract: Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis. Dysregulated production of fat-derived secretory factors, adipocytokines, is partly responsible for obesity-linked metabolic disorders. However, the mechanistic role of obesity per se to adipocytokine dysregulation has not been fully elucidated. Here, we show that adipose tissue of obese mice is hypoxic and that local adipose tissue hypoxia dysregulates the production of adipocytokines. Tissue hypoxia was con… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

40
914
4
26

Year Published

2012
2012
2021
2021

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 1,076 publications
(984 citation statements)
references
References 58 publications
40
914
4
26
Order By: Relevance
“…This condition may play a role in tissue ageing as white AT in obese individuals has been shown to be hypoxic (Trayhurn et al 2008;Ye et al 2007;Hosogai et al 2007) (reviewed by Trayhurn et al 2008(Trayhurn et al 2008). Research on human adipocytes has revealed that hypoxia induces the expression of certain inflammation-related adipokines, for example adiponectin, leptin, and interleukin-6.…”
Section: Ageingmentioning
confidence: 99%
“…This condition may play a role in tissue ageing as white AT in obese individuals has been shown to be hypoxic (Trayhurn et al 2008;Ye et al 2007;Hosogai et al 2007) (reviewed by Trayhurn et al 2008(Trayhurn et al 2008). Research on human adipocytes has revealed that hypoxia induces the expression of certain inflammation-related adipokines, for example adiponectin, leptin, and interleukin-6.…”
Section: Ageingmentioning
confidence: 99%
“…Hypoxic stress plays a pivotal role in normal human development and physiology, including embryogenesis and wound repair, and has been well studied for its importance in the pathogenesis of several human diseases, including heart disease, stroke, diabetes, and cancer (Gore et al, 2010). In adipose tissue of obese mice there is evidence for hypoxia, which elicits dysregulated production of adipocytokines and downregulates adiponectin expression by mediation of endoplasmic reticulum stressdependent transcriptional and -independent posttranscriptional mechanisms (Hosogai et al, 2007). Therefore, local hypoxia in adipose tissue may provide cellular mechanisms for chronic inflammation, macrophage infiltration, adiponectin reduction, leptin elevation, adipocyte death, endoplasmic reticulum stress and mitochondrial dysfunction in obesity.…”
Section: Hypoxiamentioning
confidence: 99%
“…Therefore, local hypoxia in adipose tissue may provide cellular mechanisms for chronic inflammation, macrophage infiltration, adiponectin reduction, leptin elevation, adipocyte death, endoplasmic reticulum stress and mitochondrial dysfunction in obesity. The concept suggests that inhibition of adipogenesis and triglyceride synthesis by hypoxia may be a new mechanism for elevated free fatty acids in the circulation in obesity (Hosogai et al, 2007;Woods et al, 2009). …”
Section: Hypoxiamentioning
confidence: 99%
“…Nevertheless, to our knowledge there are no studies trying to ameliorate the hypoxic state within adipose tissue. Indeed, recent investigations have suggested that adipose tissue hypoxia provides a cellular explanation for chronic inflammation and macrophage infiltration in white adipose tissue in obesity [22,60], which have been associated to some complications accompanying obesity-related diseases.…”
Section: Introductionmentioning
confidence: 99%