Adipose tissue, systematic inflammation, and neurodegenerative diseases

Chronic Low Back Pain Improves More With Cognitive Functional Therapy Than With Core Exercises

“…1 Studies also show that adipose tissue can lead directly to neuroinflammation, which may worsen chronic pain 1 and as an inflammatory state can lead to increased irritation of surrounding muscles and nerves, worsening the experience of pain. Although the studies show neuroinflammation affecting cognitive changes from excess adiposity, 19 this may be extrapolated to theorize on how pain may be affected. Obesity leads to an increased amount of adipose tissue, which perpetuates further insulin and leptin resistance contributing to metabolic syndrome.…”

“…20 Studies on adiposity and pain often conclude that exercise is good for both decreasing adiposity and pain, but the data cannot be linked linearly from obesity reduction causing pain reduction, and in fact many studies do not show weight loss as effective for pain attenuation. 15,19 Despite evidence suggesting no causal relationship between obesity and pain, there is evidence to show that chronic pain increases disability and decreases overall physical functioning in those patients with an elevated BMI as compared with their BMI less than 25 counterparts, 15 most likely related to the factors mentioned above, including increased mood disorders.…”

Diagnosis and Management in Patients With Pain in the Setting of Obesity

“…Studies also show that adipose tissue can lead directly to neuroinflammation, which may worsen chronic pain1 and as an inflammatory state can lead to increased irritation of surrounding muscles and nerves, worsening the experience of pain. Although the studies show neuroinflammation affecting cognitive changes from excess adiposity,19 this may be extrapolated to theorize on how pain may be affected. Obesity leads to an increased amount of adipose tissue, which perpetuates further insulin and leptin resistance contributing to metabolic syndrome 20.…”

“…This then leads to increased amounts of leptin, which has been shown to lead to cartilage degradation through inflammatory means such as increased proinflammatory mediators and matrix metalloproteinases 20. Studies on adiposity and pain often conclude that exercise is good for both decreasing adiposity and pain, but the data cannot be linked linearly from obesity reduction causing pain reduction, and in fact many studies do not show weight loss as effective for pain attenuation 15,19…”

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

“…Far from being merely a fat storage organ, the AT is a fundamental endocrine organ for the entire body (Scheja & Heeren, 2019). Therefore, alterations in the secretion and systemic level of these adipokines may contribute to the development of many health problems as previously described, including numerous neurodegenerative diseases such as AD (de A Boleti et al, 2023).…”