Adipose tissue-to-breast cancer crosstalk: Comprehensive insights

Wu, Yujuan; Xu, Li; Li, Qiong; Cheng, Chien-Shan; Li, Zheng

doi:10.1016/j.bbcan.2022.188800

Cited by 22 publications

(13 citation statements)

References 355 publications

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“…After all, the understanding of adipose tissue as a passive energy reservoir is no longer sustained, and this tissue is already considered a crucial endocrine organ in regulating metabolism. These endocrine actions involve its ability to secrete a variety of adipokines, which participate in signaling roads that may even relate to obesity and cancer [22]. Furthermore, excessive adipose tissue accumulation tends to generate insulin resistance and diabetes [23].…”

Section: Resultsmentioning

confidence: 99%

Correlations between health indicators in women who survived breast cancer

Paixão

Leite²,

Cunha³

et al. 2023

Sci. Plena

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The increase in breast cancer survivors (BCS) has established unprecedented demands on health systems worldwide. In this context, new knowledge is needed to subsidize strategies to handle this population. The objective of this study was to combine the correlations between anthropometric, hematological, biochemical, biophysicochemical, muscle strength, and age variables in BCS. Twenty-two volunteers (51.7 ± 9.2 years old) with a history of mastectomy and lymphadenectomy participated in the study. Among the results, the correlations of the body mass index with lipid profile, strength, and body composition draw special attention. The associations of lipid profile with erythrocyte membrane stability, body composition, and leukocyte count, the associations of the red cell distribution width (RDW) with body mass index, lipid profile, and strength, and the positive correlation between age and leukocyte count also deserve highlights. Such findings allow concluding that investigations that deal singly with health indicators represent a severe limitation in the study of the public in question, and it is necessary to avoid them. The complex network of interactions observed between the various parameters studied reinforces the importance of a global biological analysis of attractive cost-benefit and great practical potential. Teams with medical, nutrition, physical therapy, and physical education professionals, among other areas, can use this knowledge to improve BCS's interdisciplinary approaches in short, medium, and long-term management.

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Section: Resultsmentioning

confidence: 99%

Correlations between health indicators in women who survived breast cancer

Paixão

Leite²,

Cunha³

et al. 2023

Sci. Plena

View full text Add to dashboard Cite

show abstract

“…Studies have shown that white adipose tissue (WAT) is associated with the risk of breast cancer and prostate cancer [85,86]. In some cancer-related cachexia, the transformation of white adipocytes to brown adipocytes and atrophy may contribute to the exacerbation of cachexia [87,88]. Brown adipocytes are cells that break down metabolic substrates such as glucose to generate heat.…”

Section: Adipocytesmentioning

confidence: 99%

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Tan

Yang

et al. 2023

J Exp Clin Cancer Res

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Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes.

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“…Breast cancer has been the most commonly diagnosed cancer worldwide, and its burden had been rising over the past decades. 44,45 It was reported that PLC could regulate the invasiveness and migration of breast tumor cells, has a correlation with breast tumor grade, and has been used as a potential marker for the clinical outcome of breast cancer. 46,47 In order to study the analytical applicability of the PFcMMA/Zr 4+ /PE/ Cys/Au sensor, PLC from human mammary cell lines MCF-7 (cancer cells), MDA-MB-231 (cancer cells) and MCF-10A (normal cells) was analyzed and the results were compared with those determined using a commercial ELISA kit.…”

Section: Real Sample Analysismentioning

confidence: 99%