Adiposidade Corporal e Apolipoproteínas em Crianças e Adolescentes: Metanálise de Estudos Prospectivos

Abstract

Background: Excess Weight and Cardiovascular Diseases are health problems with increasing prevalence among children and adolescents, hence the need to investigate the issues related to them to better deal with the problem. Objective: To investigate the influence of excess adiposity on the levels of apolipoprotein B and A1 in children and adolescents. Methods: A systematic search was conducted in the PubMed, Embase, Lilacs, Web of Science, Ovid and Science direct databases, searching for cohort eligible studies and evaluating their results, methodological quality and risk of bias; combinable studies with good quality and low risk of bias were evaluated by meta-analysis. The summary measure used was the weighted mean difference (WMD) with its respective 95% confidence interval. Results: 8 articles attended the eligibility criteria including individuals with age mean varying from 9 to 15.7 years of age. The meta-analysis included 4 articles with a total of 7,974 children and adolescents. It was observed a mean increase of 4,94mg/dL (95%CI: 4,22 to 5,67) in the ApoB levels in individuals with excess of body adiposity. For the ApoA1, we identified a mean reduction of-8,13mg/dL (95%CI:-9,09 to-7,17 mg/dL) in its levels in children and adolescents with higher body adiposity. Beside this, the influence of excess adiposity on the ApoB and ApoA1 levels was higher between adolescents than children. Conclusions: The excess of body adiposity influenced both the reduction of ApoA1 values and the increase of ApoB levels, being these changes more relevant among adolescents.

Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness

“…A meta-analysis of eight studies with mean ages of nine to 15.7 years found an average reduction of 8.13mg/dL (95%CI: -9.09- -7.17mg/dL) and an average increase of 4.94mg/dL (95%CI: 4.22-5.67mg/dL) of apolipoprotein A1 and B in overweight and obese children and adolescents. ( 17 ) Apolipoprotein A1 has the ability to modulate the energy expenditure of adipocytes, reduce atherosclerosis, and lead to the accumulation of hepatic lipids, as well as inflammation; this protein is considered a protective factor for CVD. ( 18 ) On the other hand, apolipoprotein B is related to atherogenic particles, and its levels are directly associated with hypertension, central obesity, and insulin resistance, increasing the risk of CVD.…”

Alimentação E Saúde: Uma Análise Sobre O Consumo De Produtos Orgânicos Durante a Pandemia Da Covid-19

“…Contudo, a falta de tempo dos responsáveis e o crescente número de mulheres no mercado de trabalho tem facilitado o acesso das crianças a refeições fora de casa e de comidas industrializadas, com altos valores energéticos e grande quantidade de açúcares, sódio e gorduras (BENTO, 2010). Tal questão tem gerado impacto direto no aumento do número de doenças crônicas não transmissíveis em crianças, como hipertensão, diabetes melittus e doenças cardiovasculares (JESUS et al, 2020).…”

Panorama Da Obesidade Em Crianças E Adolescentes E Os Riscos Cardiovasculares

“…Na infância, a obesidade está associada ao surgimento de inúmeras comorbidades futuras, tais como: Hipertensão Arterial Sistêmica (HAS), Diabetes Mellitus tipo 2 (DM2) e Acidente Vascular Cerebral (AVC), além de problemas sociais e psicológicos (JESUS et al, 2020). O excesso de adiposidade corporal desde o período infantil, apresenta relação com o surgimento de dislipidemia e doenças ateroscleróticas ainda na infância, aumentando o risco do desenvolvimento de morbidades cardiovasculares na idade adulta (BARROSO et al, 2020).…”