Adiposity as a full mediator of the influence of cardiorespiratory fitness and inflammation in schoolchildren: The FUPRECOL Study

García-Hermoso, António; Agostinis‐Sobrinho, César; Mota, Jorge; Santos, Rute; Correa-Bautista, Jorge Enrique; Ramírez‐Vélez, Robinson

doi:10.1016/j.numecd.2017.04.005

Cited by 18 publications

(10 citation statements)

References 49 publications

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“…Similar results were found in young Spanish adults in which different body composition variables such as BMI, waist circumference, fat mass percentage acted as mediators between CRF and blood pressure 30 . Likewise, in 935 Colombian children and adolescents, García-Hermoso, Agostinis-Sobrinho, Mota, Santos, Correa-Bautista, Ramírez-Vélez 31 showed that high levels of CRF might not counteract the negative consequences ascribed to adiposity on inflammation.…”

Section: Discussionmentioning

confidence: 99%

The role of body fat in the relationship of cardiorespiratory fitness with cardiovascular risk factors in Brazilian children

Brand

Dias

Fochesatto

et al. 2018

Motriz: rev. educ. fis.

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To analyze the association between the percentage of body fat and cardiorespiratory fitness (CRF) with cardiovascular risk factors in children, and; to examine whether percentage of body fat acts as a mediator on the association between CRF and cardiovascular risk factor. Methods: This cross-sectional study included 128 children aged 7-11 years (Mean 8.54, SD: 1.42). The following variables were evaluated: the percentage of body fat, CRF, diastolic and systolic blood pressure, glucose, triglycerides (TG) and total cholesterol. For statistical analysis were performed Partial correlation and mediation analysis. All analysis was adjusted for sex, age and height. Results: CRF, the percentage of body fat, mean arterial pressure (MAP) and TG showed a correlation between each other. Percentage of body fat mediated the association between CRF and MAP (Indirect Effect=-0.008; IC:-0.0159-0.0030), explaining 29% of this association. However, it was found that the percentage of body fat was not a mediator of the association between CRF and TG. Conclusion: The percentage of body fat mediates the association between CRF and MAP. Our findings show that the importance of a healthy body composition for the prevention of high blood pressure levels in childhood as well as the relevance of physical activity on these parameters.

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Section: Discussionmentioning

confidence: 99%

The role of body fat in the relationship of cardiorespiratory fitness with cardiovascular risk factors in Brazilian children

Brand

Dias

Fochesatto

et al. 2018

Motriz: rev. educ. fis.

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“…This may be especially relevant in individuals with systemic low-grade inflammation. 27 T A B L E 1 Differences in WBC subfraction concentration stratified in groups by CRF (low, moderate, and high) and PA categories (active vs Several studies have shown that higher CRF levels in youth are associated with better health 28 and a decrease in the production of inflammatory markers, [6][7][8]29 providing a greater anti-inflammatory state, which is important in the prevention of cardiovascular diseases. 1 The current study found that CRF is inversely associated with total WBC and segmented neutrophils concentration in youths of both sexes.…”

Section: Discussionmentioning

confidence: 99%

“…exercise, immune system, moderate-to-vigorous physical activity, physical fitness, sedentary time fitness (CRF) [6][7][8] have an inverse relationship with several inflammatory markers (eg, c-reactive protein-CRP) in children and adolescents. Carlsson et al 2 suggested that physical inactivity (ie, not achieving the minimal international PA recommendations of 60 min/day of MVPA) and self-reported sedentary behaviors may alter the immune activity and facilitate an autoimmune reaction.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory fitness, physical activity, sedentary behavior, and circulating white blood cells in US youth

García-Hermoso

Ramírez‐Vélez

Alfonso-Rosa

et al. 2020

Scandinavian Med Sci Sports

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The white blood cell (WBC) count indicates the number of white blood cells (ie, neutrophils, lymphocytes, monocytes, basophils, and eosinophils) in a sample of blood. High or extremely low total WBC counts in circulation at resting conditions could be related to the presence of illness. White blood cells are made in the bone marrow and protect the body against infection and aid in the immune response. 1 Importantly, the WBC count is considered a clinical marker that reflects inflammatory processes related to cardiometabolic disorders involved in the development of cardiovascular diseases (CVD). 1 Existing research recognizes the critical role physical activity (PA) plays on the immune system of children 2 by inducing both a short-term pro-inflammatory effect and a long-term anti-inflammatory effect, a dual response that is mediated by the coordinated activation of numerous cytokines and chemokines. 3 Previous research has established that moderate-to-vigorous PA (MVPA) 4,5 and cardiorespiratory

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“…Recently, Fraser and colleagues [ 18 ], in a longitudinal study of 20 years, demonstrated that childhood MF and CRF were associated with beta cell function and insulin resistance in adulthood. Previously, our group has shown that CRF [ 15 , 16 , 39 ] and MF [ 17 , 20 , 28 ] were inversely associated with metabolic risk factors. However, in these studies, the analysis of the combined effect of adherence to a MeDiet and both fitness components on cardiometabolic health was not possible due to the small number of adolescents in the groups.…”

Section: Discussionmentioning

confidence: 99%

Optimal Adherence to a Mediterranean Diet May Not Overcome the Deleterious Effects of Low Physical Fitness on Cardiovascular Disease Risk in Adolescents: A Cross-Sectional Pooled Analysis

et al. 2018

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To examine the combined association of cardiorespiratory fitness (CRF), muscular fitness (MF), and adherence to a Mediterranean diet (MeDiet) on cardiovascular risk in adolescents, a pooled study, including cross-sectional data from two projects [2477 adolescents (1320 girls) aged 12–18 years], was completed. A shuttle run test was used to assess CRF. MF was assessed by the standing-long jump and handgrip tests. Adherence to a MeDiet was assessed by the Kidmed questionnaire. A cardiovascular risk score was computed from the following components: Age and sex, waist circumference, triglycerides, systolic blood pressure, high-density lipoprotein cholesterol (HDL), and glucose. Analysis of covariance showed that participants classified as having optimal (High) adherence to a MeDiet/HighMF/HighCRF, as well those classified as low adherence to a MeDiet/HighMF/HighCRF, had, on average, the lowest cardiovascular risk score (F = 15.6; p < 0.001). In addition, the high adherence to a MeDiet/LowMF/LowCRF group had the highest odds of having a high cardiovascular risk (OR = 7.1; 95% CI: 3.4–15.1; p < 0.001), followed by the low adherence to a MeDiet/LowMF/LowCRF group (OR = 3.7; 95% CI: 2.2–6.3; p < 0.001), high adherence to a MeDiet/HighMF/LowCRF group (OR = 3.1; 95% CI: 1.4–7.0; p = 0.006), and low adherence to a MeDiet/LowMF/HighCRF group (OR = 2.5; 95% CI: 1.5–4.4; p = 0.002) when compared to those with high adherence to a MeDiet/HighMF/HighCRF, after adjustments for potential confounders. In conclusion, our findings showed that, regardless of the MeDiet status, adolescents with low MF and low CRF cumulatively, presented the highest cardiovascular disease risk. Therefore, these findings suggest that the combination of these two fitness components may be beneficial to adolescents’ cardiometabolic profile, independent of MeDiet behaviour.

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Adiposity as a full mediator of the influence of cardiorespiratory fitness and inflammation in schoolchildren: The FUPRECOL Study

Cited by 18 publications

References 49 publications

The role of body fat in the relationship of cardiorespiratory fitness with cardiovascular risk factors in Brazilian children

The role of body fat in the relationship of cardiorespiratory fitness with cardiovascular risk factors in Brazilian children

Cardiorespiratory fitness, physical activity, sedentary behavior, and circulating white blood cells in US youth

Optimal Adherence to a Mediterranean Diet May Not Overcome the Deleterious Effects of Low Physical Fitness on Cardiovascular Disease Risk in Adolescents: A Cross-Sectional Pooled Analysis

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