Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults

Li, Kaifeng; Brennan, Lorraine; Bloomfield, Jack F.; Duff, D. J.; McNulty, Breige; Flynn, Albert; Walton, Janette; Gibney, Michael J.; Nugent, Anne P.

doi:10.1002/mnfr.201700785

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…Furthermore, MCFAs have been shown to be associated with anti-inflammatory activities [ 64 ] and cardioprotective effects by raising high-density lipoproteins [ 65 ] and reducing blood pressure and heart rate [ 66 ]. Therefore, replacing SFAs with alternative ingredients to prevent obesity-related metabolic disturbances and its related risks for CVD has gained substantial attention [ 67 , 68 ]. Recent studies suggest that diet-induced obesity (DIO) in rats alters cytokine production and impairs liver function and morphology in response to acute inflammatory stimuli such as LPS.…”

Section: Discussionmentioning

confidence: 99%

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Son

Kim

Lee

et al. 2022

IJERPH

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This study investigated the effects of partial replacement of dietary fat with krill oil (KO) or coconut oil (CO) on dyslipidemia and lipid metabolism in rats fed with a high-fat diet (HFD). Sprague Dawley rats were divided into three groups as follows: HFD, HFD + KO, and HFD + CO. The rats were fed each diet for 10 weeks and then intraperitoneally injected with phosphate-buffered saline (PBS) or lipopolysaccharide (LPS) (1 mg/kg). The KO- and CO-fed rats exhibited lower levels of serum lipids and aspartate aminotransferases than those of the HFD-fed rats. Rats fed with HFD + KO displayed significantly lower hepatic histological scores and hepatic triglyceride (TG) content than rats fed with HFD. The KO supplementation also downregulated the adipogenic gene expression in the liver. When treated with LPS, the HFD + KO and HFD + CO groups reduced the adipocyte size in the epididymal white adipose tissues (EAT) relative to the HFD group. These results suggest that KO and CO could improve lipid metabolism dysfunction.

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Section: Discussionmentioning

confidence: 99%

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Son

Kim

Lee

et al. 2022

IJERPH

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“…As with SFA, PUFA can be further characterised based on their carbon chain length, wherein PUFA with greater than twenty carbon atoms are referred to as LC PUFA. There is conflicting evidence relating to the inflammatory status of n -6 PUFA ( 19 ) , nevertheless evidence suggests that intakes of linoleic acid (LA) are associated with reduced adiposity ( 20 ) , CHD ( 21 ) and mortality ( 22 ) and improved glycaemic control ( 23 ) . The anti-inflammatory effects of the LC n -3 PUFA, EPA and DHA are well recognised ( 14 , 24 , 25 ) .…”

Section: Dietary Fatty Acidsmentioning

confidence: 99%

Dietary fat composition: replacement of saturated fatty acids with PUFA as a public health strategy, with an emphasis on α-linolenic acid

Lenighan¹,

McNulty

Roche³

2019

Proc. Nutr. Soc.

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SFA intakes have decreased in recent years, both in Ireland and across other European countries; however a large proportion of the population are still not meeting the SFA recommendation of <10% of total energy (TE). High SFA intakes have been associated with increased CVD and type-2 diabetes (T2D) risk, due to alterations in cholesterol homoeostasis and adipose tissue inflammation. PUFA, in particular EPA and DHA, have been associated with health benefits, including anti-inflammatory effects. It is well established that dietary fat composition plays an important role in biological processes. A recent review of evidence suggests that replacement of SFA with PUFA has potential to reduce risk of CVD and T2D. The public health and molecular impact of EPA and DHA have been well-characterised, while less is known of effects of α-linolenic acid (ALA). The current dietary guideline for ALA is 0·5% TE; however evidence from supplementation trials suggests that benefit is observed at levels greater than 2 g/d (0·6–1% TE). This review highlights the gap in the evidence base relating to effects of the replacement of SFA with ALA, identifying the need for randomised controlled trials to determine the optimal dose of ALA substitution to define the efficacy of dietary fat modification with ALA.

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“…The polyunsaturated fatty acids group includes essential fatty acids such as linoleic acid (n-6) and α-linolenic acid (n-3) (Ivanko, 2012;FAO, 2010). The linoleic acid reduces risk of coronary heart disease, adiposity, mortality, improves glycaemic control (Wu et al, 2014;Farvid, 2015;Belury et al, 2018;Li et al, 2018) and α-linolenic acid improves inflammation, hepatic steatosis, insulin sensitivity, and risk of coronary heart disease (Lenighan et al, 2019). The aim of the study was to determinate the values of bioactive compounds and fatty acid profile in white dried grape pomace Vitis vinifera "Pinot Gris".…”

Section: Introductionmentioning

confidence: 99%

Bioactive compounds and fatty acid profile of grape pomace

Vašeková

Juráček

Bíro

et al. 2020

Acta fytotechn zootechn

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Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults

Abstract: Plasma LA is inversely associated with adiposity, followed by haplotypes of FADS1/2 genes, carbohydrate intakes, and dietary PUFA intakes. The association observed between plasma LA and adiposity may be linked to decreased de novo lipogenesis, insulin resistance, and inflammation.

Cited by 6 publications

References 69 publications

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Dietary fat composition: replacement of saturated fatty acids with PUFA as a public health strategy, with an emphasis on α-linolenic acid

Bioactive compounds and fatty acid profile of grape pomace

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