Adiposity, fitness and metabolic risk in children: A cross-sectional and longitudinal study

Puder, Jardena J.; Schindler, Christian; Zahner, Lukas; Kriemler, Susi

doi:10.3109/17477166.2010.533774

Cited by 18 publications

(19 citation statements)

References 39 publications

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“…Therefore, the precise role of CRP in the development of CVD risk factors in humans remains unknown. In our study, CRP was positively correlated to fatness, similar to findings from several studies in youth [15,16,17,18,21,26,29]. Moreover, a significant correlation between CRP and the clustered z-score was only found in the group with S4SF values above the median.…”

Section: Discussionsupporting

confidence: 79%

“…CRP was not significantly correlated to VO 2peak after adjusting for S4SF. Other studies have found negative correlations between VO 2peak and CRP in youth [26,27,29,30]. Two of these studies found that the correlation was not significant after adjusting for fatness [27,30], like we did.…”

Section: Discussionmentioning

confidence: 48%

“…Negative correlations have been found between VO 2peak and some markers of low-grade inflammation, e.g. CRP [26,27,29,30] and TNFα [19], whereas others found a positive correlation between TNFα and VO 2peak [28]. The relation between the anti-inflammatory markers sTNFR1 and IL-1Ra and the level of body fatness and VO 2peak has not yet been studied in youth populations.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

et al. 2012

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Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO_2peak) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO_2peak was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values <0.05). The associations with adiponectin, CRP and IL-6 were stronger for the fattest adolescents. VO_2peak was negatively correlated with clustered z-score, adiponectin and IL-6 and positively related to systolic blood pressure. The sum of four skinfolds was inversely related to adiponectin and positively correlated to body mass index, systolic blood pressure, homeostasis model assessment, clustered z-score and CRP. Conclusion: In adolescents, CVD risk was associated with alternations in adiponectin, TNFα, CRP and IL-6, and related to both VO_2peak and fatness.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

et al. 2012

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“…This is similar to findings in adults [16,29] and children [23], although in two of these studies no difference between high-fit and low-fit overweight individuals was observed, possibly due to poor measures of fatness and fitness [16] or low number (n = 4) of high-fit/overweight participants [23]. Similarly, girls with the same baseline adiposity level had lower longitudinal increase in CRP if baseline fitness was higher [42]. Unfortunately, no empirical classifications for fitness FFM exist.…”

Section: Discussionmentioning

confidence: 91%

Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents

et al. 2015

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IntroductionThe interaction between fatness, fitness, and C-reactive protein (CRP) in adolescents is not well characterized but may be important to prevent low grade inflammation. The purpose of this study was to assess the relationship between adiposity, different expressions of fitness, and CRP in late adolescence using direct measures of fitness and fatness.MethodsAnthropometric measurements were taken on 245 eighteen-year-old participants (116 girls). Fasting CRP, glucose, and insulin were measured and homeostatic model assessment (HOMA) calculated. Body composition was estimated via dual energy X-ray absorptiometry. Fitness was assessed with maximal oxygen uptake (VO2max) during a treadmill test and also expressed relative to the fat-free mass (VO2maxFFM).ResultsPrevalence of overweight/obesity based on body mass index (BMI) was 20.7% and 25.6% among girls and boys, respectively (p = 0.407), but 42.5% and 58.1% when based on body fat percentage (%fat, p = 0.015). Higher proportion of boys (81.3%) than girls (54.5%) were highly fit (p<0.001), but the percentage of girls with high levels of CRP was greater (12.1% vs 6.2%, p = 0.028). Adiposity, indicated with BMI, waist circumference, fat mass, android fat mass (aFM), or %fat, was positively associated with CRP independent of VO2max (r = 0.13-0.18, p<0.05) and VO2maxFFM (r = 0.24-0.32, p<0.001). VO2max, was negatively associated with CRP independent only of BMI and waist circumference (r = -0.21, p = 0.001), but not %fat, fat mass or aFM (r = -0.08 to -0.12, p>0.05). VO2maxFFM was unrelated to CRP with (r = -0.07 to -0.11, p>0.05) or without (r = -0.10, p = 0.142) adjustment for adiposity. Additional adjustment for HOMA did not change any of the relationships, although the coefficients were attenuated.ConclusionsFatness has a greater association with CRP than fitness in late adolescence. However, VO2maxFFM, which is truly independent of adiposity, is unrelated to CRP, indicating that the effects of fitness might be mediated via the fatness component embedded in fitness expressed relative to body mass.

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“…However, Owen et al 22 , in the CHASE study, reported a strong association between PA measured objectively and CRP in a sample of Caucasian-European, Southern-Asiatic, and Afro-Caribbean children. While some studies with young subjects find negative associations between PA or cardiorespiratory fitness and CRP 2,22,23,24,25,26,27 , others do not 21,28,29,30,31,32,33,34,35,36 . Moreover, in many of these studies, the results are not presented independently from the body mass index (BMI), a potentially confounding variable of the relationship between CRP and PA or cardiorespiratory fitness 37 .…”

Section: Introductionmentioning

confidence: 99%

Proteína C-reativa, atividade física e aptidão cardiorrespiratória em adolescentes portugueses: um estudo transversal

et al. 2015

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Adiposity, fitness and metabolic risk in children: A cross-sectional and longitudinal study

Abstract: isrctn.org 15360785.

Cited by 18 publications

References 39 publications

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents

Proteína C-reativa, atividade física e aptidão cardiorrespiratória em adolescentes portugueses: um estudo transversal

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