Adiposity markers and lung function in smokers: a cross-sectional study in a Mediterranean population

Sorlí-Aguilar, Mar; Martín-Luján, Francisco; Flores-Mateo, Gemma; Jardí-Piñana, Cristina; Aparicio, Estefanía; Basora, Josep; Solà, Rosa

doi:10.1186/s12890-016-0341-y

Cited by 16 publications

(15 citation statements)

References 40 publications

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“…As mentioned previously, measures such as WC are more accessible, but cannot differentiate abdominal compartments, which is the main objective of this study. WC and PF results, as other body measures in this same population, can be found in previous publication [ 19 ]; the present findings are in accordance with other previous studies that had investigated central obesity by different measure methods and research settings [ 20 , 21 ].…”

Section: Discussionsupporting

confidence: 93%

Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort

et al. 2017

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BackgroundSeveral studies have verified body fat distribution in association with pulmonary function (PF), mainly waist circumference, but few have used measures able to distinguish abdominal fat compartments. The present study aims to verify the association of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with PF measures.MethodsIn 1982, all hospital births occurring in Pelotas, Brazil, were identified and those livebirths have been followed. In 2012–13, the cohort participants were evaluated and VAT and SAT measured using ultrasound; forced expiratory volume in the first second (FEV1) or forced vital capacity (FVC) were patronized in z-scores stratified by sex. The associations were verified using crude and adjusted linear regressions.ResultsThe present analyses comprised 3438 individuals (1721 women). VAT was inversely associated with spirometric parameters, in both crude and adjusted models. SAT showed inverse associations in the crude analyzes in males and a positive trend after adjustment, except for SAT and FVC in males. To each centimeter of VAT, mean adjusted FEV1 z-scores decreased 0.072 (95% CI -0.107; −0.036) in men and 0.127 (95% CI -0.164; −0.090) in women, and FVC z-scores decreased −0.075 (95% CI -0.111; −0.039) and 0.121 (95% CI -0.158; −0.083), in men and women, respectively.ConclusionsVAT has a consistent inverse association with FEV1 and FVC in both sexes. On the other hand, SAT showed inconsistent results with PF parameters.Electronic supplementary materialThe online version of this article (10.1186/s12890-017-0510-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort

et al. 2017

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“…The results of the previous studies regarding the association between BMI and FEV 1 or FVC were inconclusive. 13,[28][29][30][31][32] A cross-sectional study based on the British community did not find a linear association between BMI and FEV 1 or FVC among 2633 adults, which was in accordance with our results. 30 However, a cross-sectional study conducted in Mediterranean smokers found that BMI was inversely associated with lung function.…”

Section: Discussionsupporting

confidence: 91%

“…Some studies showed that gender modified the effect of obesity on lung function. 13,42 In our analyses, the inverse Notes: † Models were adjusted for gender (male/female), age (continuous), height (continuous), weight (continuous), city (Wuhan/Zhuhai), occupational hazard exposure (yes/no), drug status (yes/no), smoking status (smokers/nonsmokers), drinking status (drinkers/nondrinkers), regular physical activity (yes/no), cooking meals at home (yes/ no), and family income (≥40,000/<40,000 RMB/year). ‡ Models were adjusted for † models without height (continuous).…”

Section: Discussionmentioning

confidence: 99%

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<p>Systemic Inflammation Mediates the Associations Between Abdominal Obesity Indices and Lung Function Decline in a Chinese General Population</p>

He¹,

Wang²,

Zhou³

et al. 2020

DMSO

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Background: Previous studies reported that obesity indices were inversely associated with lung function. However, the underlying mechanisms remain unclear. We aimed to assess the potential mediating effect of systemic inflammation in the associations between obesity indices and lung function decline among a general population. Methods: We conducted a cross-sectional study among 3442 participants from the Wuhan-Zhuhai cohort. Plasma C-reactive protein (CRP) was assayed as a marker of systemic inflammation. The relationships among several obesity indices (body mass index, BMI; waist circumference, WC; waist-to-hip ratio, WHR; waist-to-height ratio, WHtR), plasma CRP and lung function were assessed by generalized linear models. The role of CRP in the associations between obesity indices and lung function was analyzed using mediation analysis. Results: We observed inverse associations between abdominal obesity indices (WC, WHR and WHtR) and lung function parameters, including forced expiratory volume in 1 s (FEV 1) and forced vital capacity (FVC) (all P<0.05). Each 1-unit increase in WC was associated with a 3.39 mL decrease in FEV 1 and a 3.96 mL decrease in FVC (all P<0.05). Each 1% increase in WHR and WHtR was associated with a 5.42 mL and a 14.23 mL decrease in FEV 1 , and a 5.70 mL and a 16.92 mL decrease in FVC (all P<0.05). Mediation analysis indicated that plasma CRP partly mediated the associations between abdominal obesity and lung function. The mediated proportions of CRP in associations of WC, WHR and WHtR with FEV 1 were 7.96%, 9.59% and 5.76%, respectively. The mediated proportions of CRP in associations of WC and WHR with FVC were 8.33% and 11.40%, respectively. Conclusion: Abdominal obesity indices were negatively associated with lung function, and the associations may be partly mediated by systemic inflammation.

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“…This distinction is important because central obesity—which can be assessed by waist circumference (WC)—likely has a direct mechanical effect on pulmonary function. Indeed, central obesity is a marker of visceral adipose tissue, and is a critical determinant of a restrictive (rather than obstructive) spirometric pattern . On the other hand, general obesity is typically associated with a chronic state of low‐grade inflammation, and this likely contributes to increased airway wall thickness, increased baseline airway tone and increased vascular congestion of the airway wall …”

Section: Introductionmentioning

confidence: 99%

BMI but not central obesity predisposes to airway closure during bronchoconstriction

et al. 2019

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Background and objective: Obesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. This study investigates the effect of body mass index (BMI) versus waist circumference (WC) on spirometric lung function, sensitivity to airway narrowing and closure, and airway closure during bronchoconstriction in patients with asthma. Methods: Participants underwent spirometry and methacholine challenge. Sensitivity to airway closure and narrowing was assessed from the dose-response slopes of the forced vital capacity (FVC) and the ratio of forced expiratory volume in 1 s (FEV 1 ) to FVC, respectively. Airway closure during bronchoconstriction (closing index) was computed as the percent reduction in FVC divided by the percent reduction in FEV 1 at maximal bronchoconstriction. Results: A total of 116 asthmatic patients (56 obese) underwent methacholine challenge. Spirometric lung function was inversely related to WC (P < 0.05), rather than BMI. Closing index increased significantly during bronchoconstriction in obese patients and was related to increasing BMI (P = 0.01), but not to WC. Sensitivity to airway closure and narrowing was not associated with BMI or WC. Conclusion: Although WC is associated with restrictive effects on baseline lung function, increased BMI, rather than WC, predisposes to airway closure during bronchoconstriction. These findings suggest that obesity predisposes to airway closure during bronchoconstriction through mechanisms other than simple mass loading.

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Adiposity markers and lung function in smokers: a cross-sectional study in a Mediterranean population

Cited by 16 publications

References 40 publications

Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort

Visceral and subcutaneous abdominal adiposity and pulmonary function in 30-year-old adults: a cross-sectional analysis nested in a birth cohort

<p>Systemic Inflammation Mediates the Associations Between Abdominal Obesity Indices and Lung Function Decline in a Chinese General Population</p>

BMI but not central obesity predisposes to airway closure during bronchoconstriction

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