Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women

The prevalence of both obesity and allergy has been increasing throughout the world, leading to the hypothesis that the two are linked to one another. This overview summarizes the results of 34 studies from 2002 to 2012 that investigated a possible contributing effect of increasing body mass on the development and prevalence of various atopic diseases. Obesity was found to clearly affect bronchial asthma. However, the correlation was stronger in the nonatopic asthma phenotype. Obesity was found to be associated with the development of atopic dermatitis in children only. No clear association was found between obesity and the prevalence of allergic rhinitis or allergic conjunctivitis or increased sensitization to food allergens. This review sums up our study results and discusses a possible role of obesity in the promotion of allergy and asthma.

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Obesity - A Promoter of Allergy?

Baumann

Lorentz²

2013

“…In particular, the risk of allergic sensitization increased with lower HDL and higher LDL levels [48], especially in females. Therefore, it has been hypothesized that contrasting reports on the association between serum cholesterol and atopy and confounding factors could be the expression of differences in race and/or other demographic variables.…”

Section: Resultsmentioning

confidence: 99%

Association between Allergies and Hypercholesterolemia: A Systematic Review

Manti

Cuppari²,

Marseglia³

et al. 2017

Background: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. Methods: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations. Information on the study design, sample, intervention, comparators, outcome, time frame, and risk of bias were abstracted for each article. Results: Of 601 reviewed reports, 18 were included in this systematic review. Fifteen studies assessed the relationship between AP and serum cholesterol levels. Due to the lack both of observational and cross-sectional studies from the literature search at this time (only 8 studies also analyzed confounding factors) there is a high possibility of confounding variables (familial and genetic predisposition, age, gender, BMI, comorbidity, and medication status) that could not be ruled out. Conclusion: Existing studies are heterogeneous, making it difficult to draw broad conclusions. Future studies and more detailed analyses, considering confounding variables and including a larger and homogeneous population, are needed to strengthen the argument for a link between lipid metabolism and atopy.

“…Asthma is a systemic inflammation, and multiple mechanisms and biomarkers such as high-sensitivity C-reactive protein [32], tumor necrosis factor-α, IL-6, IL-8 [33] and fibrinogen [34] have been associated with this disease, which are not necessarily specific to the Th2 immunity profile and atopy. Another possible explanation for the link between asthma and HDL-C is the share of a common genetic influence between low HDL-C and allergic sensitization, as suggested in a report in 1,187 Chinese twins [35]. In the setting of a genetic link between low HDL-C and allergic sensitization, common adverse environmental influences (e.g.…”

Section: Discussionmentioning

confidence: 99%

Asthma: The Role of Low High-Density-Lipoprotein Cholesterol in Childhood and Adolescence

Yiallouros

Savva

Kolokotroni

et al. 2014

Background: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization. i 2014 S. Karger AG, Basel