Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study

Ohsumi, Tatsuya; Takenaka, Shoji; Sakaue, Yuuki; Suzuki, Yuki; Nagata, Ryoko; Hasegawa, Taisuke; Ohshima, Hayato; Terao, Yutaka; Noiri, Yuichiro

doi:10.1186/s12903-020-01144-0

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More importantly, combining traditional formulation with innovative technologies would also be an encouraging direction in the future. Sonic toothbrushes, as a popular daily‐used device, have been verified to improve the mechanical rinsing effectiveness of typical antibacterial mouthwashes, which might be employed to incorporate with the SIS to promote its therapeutic performance by providing in situ suspension and absorption enhancement 162 . Similarly, mouthwash liquid, dental floss, and even denture could play a significant role when combined with newly developed technologies, demonstrating a synergistic advantage of both traditional and innovative systems.…”

Section: Challenges and Perspectivementioning

confidence: 99%

Smart intraoral systems for advanced drug delivery

Liu

Guo

et al. 2022

MedComm – Biomaterials and Applications

View full text Add to dashboard Cite

Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties.Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproduc-MedComm -Biomaterials and Applications.

show abstract

Section: Challenges and Perspectivementioning

confidence: 99%

Smart intraoral systems for advanced drug delivery

Liu

Guo

et al. 2022

MedComm – Biomaterials and Applications

View full text Add to dashboard Cite

show abstract

“…These devices operate at high frequencies, producing rapid movements of the bristle tips and generating dynamic fluid flows within the oral cavity. This dynamic action enhances the removal of biofilms, especially in hard-to-reach areas, such as the interdental sites [ 6 , 12 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Critical hydrodynamic force levels for efficient removal of oral biofilms in simulated interdental spaces

Hotic,

Ackermann,

Bopp

et al. 2024

Clin Oral Invest

View full text Add to dashboard Cite

Objectives Sonic toothbrushes generate hydrodynamic shear forces for oral biofilm removal on tooth surfaces, but the effective thresholds for biofilm removal remain unexplored. This in vitro study aimed to investigate various threshold values for hydrodynamic biofilm removal in vitro. Materials and methods A specialized test bench was designed with a known water flow field within a gap, ensuring that hydrodynamic shear forces on the wall were solely dependent on the volume flow, which was quantifiable using an integrated flow meter and proven by a computational fluid dynamics simulation. A young 20 h supragingival six-species biofilm was developed on hydroxyapatite disks (∅ 5 mm) and applied into the test bench, subjecting them to ascending force levels ranging from 0 to 135 Pa. The remaining biofilms were quantified using colony forming units (CFU) and subjected to statistical analysis through one-way ANOVA. Results Volume flow measures < 0.1 l/s: Error 1% of reading were established with the test bench. Untreated biofilms (0 Pa, no hydrodynamic shear forces) reached 7.7E7 CFU/harvest and differed significantly from all treated biofilm groups. CFU reductions of up to 2.3E6 were detected using 20 Pa, and reductions of two orders of magnitude were reached above wall shear forces of 45 Pa (6.9E5). Conclusions Critical hydrodynamic force levels of at least 20 Pa appear to be necessary to have a discernible impact on initial biofilm removal. Clinical relevance Pure hydrodynamic forces alone are insufficient for adequate biofilm removal. The addition of antiseptics is essential to penetrate and disrupt hydrodynamically loosened biofilm structures effectively.

show abstract

Efficacy of Probiotic, Chlorhexidine, and Sodium Fluoride Mouthrinses on Mutans Streptococci in 8- to 12-Year-Old Children: A Crossover Randomized Trial

Gedam¹,

Katre²

2022

Lifestyle Genomics

View full text Add to dashboard Cite

Introduction: The oral cavity is home to a diverse and distinct microbiome. While the role of oral bacteria in cariogenic and other dental diseases is irrefutable, their beneficial effects in the form of probiotics (PB) has been less studied, especially pertaining to oral diseases in children. This study compares the efficacy of a PB mouthrinse with 0.12% chlorhexidine (CHX) and 0.05% sodium fluoride (NaF) mouthrinse on the colony counts of mutans streptococci (MS) in children. Methods: A triple-blind crossover randomized trial between interventional groups was planned. Fifty-one children between 8 to 12 years of age were divided into three groups (I, II, and III) and were exposed to all three mouthrinses (A, B, and C) by randomized allocation for a period of two weeks with an inter-phase washout period of four weeks. Pre- and post-interventional MS counts (CFU/mL) were assessed, and the mean change was analysed using the t test (intragroup) and ANOVA (intergroup and crossover). Results: The mean changes in the colony counts obtained with the use of PB, CHX, and NaF mouthrinses were −1.0223 (−1.2201 to −0.8246), −0.9564 (−1.1503 to −0.7626), and −0.9511 (−1.1554 to −0.7467), respectively, which were statistically significant (p < 0.0001). However, the intergroup comparison for the mean change in colony counts revealed no statistically significant differences (p > 0.05). Conclusion: The study concluded that the PB mouthrinse was equally efficacious as compared to CHX and NaF mouthrinses against MS in 8- to 12-year-old children. However, further studies are recommended to strengthen the evidence.

show abstract

Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study

Cited by 3 publications

References 36 publications

Smart intraoral systems for advanced drug delivery

Smart intraoral systems for advanced drug delivery

Critical hydrodynamic force levels for efficient removal of oral biofilms in simulated interdental spaces

Efficacy of Probiotic, Chlorhexidine, and Sodium Fluoride Mouthrinses on Mutans Streptococci in 8- to 12-Year-Old Children: A Crossover Randomized Trial

Contact Info

Product

Resources

About