Adjunctive Local Delivery of Aloe Vera Gel in Patients With Type 2 Diabetes and Chronic Periodontitis: A Randomized, Controlled Clinical Trial

Abstract

Adjunctive use of locally delivered AV gel, in comparison to locally delivered placebo gel, is associated with greater reduction in PI, mSBI, and PD as well as more gain in CAL in patients with T2DM and CP.

Comparative evaluation of subgingivally‐delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial

“…In another study by Pradeep et al. on adjunctive local delivery of AV gel in type II diabetics with chronic periodontitis, an improvement in clinical parameters was demonstrated . These results are also consistent with our present study.…”

“…After intensive in vitro investigations for optimization and stability, the MtF gel and AV gel were prepared at the Government College of Pharmacy, Bengaluru, India, following the documented procedures …”

“…In a study evaluating the effects of the local delivery of AV gel in type II diabetics with chronic periodontitis, AV gel, delivered locally into periodontal pockets, as an adjunct to SRP, in type II diabetics with chronic periodontitis, stimulated a significant improvement in clinical parameters as compared to placebo gel …”

Host modulation therapy: An updated review

“…[28] Aloe vera (AV) AV is a herbal product with antioxidant, anti-inflammatory, antimicrobial, healing-promoting, and immune-boosting properties. In a study by Pradeep et al, [29] AV gel used as an adjunct to SRP in the treatment of patients with Type 2 diabetes mellitus and CP, showed significantly greater improvement in clinical parameter compared to placebo group.…”

Aloe vera at the frontier of glycobiology and integrative medicine: Health implications of an ancient plant

“…An Indian group found that adjunctive use of locally delivered AVG, in comparison to locally delivered placebo gel, was associated with greater reduction in plaque index, modified sulcus bleeding index, and probing depth as well as more gain in clinical attachment level in patients with Type 2 diabetes mellitus and chronic periodontitis. 37 In an interesting in vitro study, a cytotoxicity assay showed that Aloe vera in prearranged concentrations was cell-compatible and indicated a dose-dependent antiviral effect of Aloe vera. 38 The inhibitory effect of various concentrations of Aloe vera was observed 1 h after the Vero cell was infected with herpes simplex virus 1 (HSV-1).…”