Adjunctive rectal misoprostol versus oxytocin infusion for prevention of postpartum hemorrhage in women at risk: A randomized controlled trial

Badejoko, Olusegun O.; Ijarotimi, Adebimpe O.; Awowole, Ibraheem O.; Loto, Olabisi Morebise; Badejoko, Bolaji O.; Olaiya, Dare S.; Fatusi, Adesegun O.; Kuti, Oluwafemi; Orji, Ernest O.; Ogunniyi, Solomon O.

doi:10.1111/j.1447-0756.2012.01869.x

Cited by 18 publications

(16 citation statements)

References 23 publications

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“…The incidence of PPH in the misoprostol group was 19.6% which was similar to 18.5% observed in the oxytocin group and comparable with 22.2% Versus 20.9% respectively reported by Badejoko et al in South West Nigeria. 17 This study demonstrated that there was no significant difference in the incidence of PPH in both groups and is also comparable to findings from previous quoted-study 17…”

Section: Discussionsupporting

confidence: 90%

“…The higher incidences of PPH recorded in our study as well as in the earlier study conducted in Nigeria utilizing adjunctive uterotonics after AMTSL17 affirms the magnitude of PPH in Nigeria to be high. This finding suggests that the incidence of PPH may have been much higher in this obstetric population in the absence of adjunctive uterotonics since all the patients had AMTSL.…”

Section: Discussionsupporting

confidence: 82%

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A prospective study to compare the effectiveness of adjunctive rectal misoprostol or oxytocin titration in the prevention of primary post-partum haemorrhage in at risk patients

et al. 2019

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Background Adjunctive uterotonic in patients at risk of primary post-partum haemorrhage may reduce its incidence. Objective To compare the effectiveness and safety of adjunctive rectal misoprostol with adjunctive intravenous oxytocin for the prevention of primary post-partum haemorrhage in at risk patients. Materials and methods A total of 122 patients with risk factors for uterine atony were allocated to receive either 600µg of rectal misoprostol (n= 61) or 20IU of oxytocin infusion (n=61) after routine management of third stage of labour. Post-partum blood loss was measured using differential delivery towel and pad weighing. Results There was similarity in the estimated post-partum blood loss, with no significant difference in the mean post-partum hematocrit levels between the adjunctive rectal misoprostol group and oxytocin infusion group (P=0.712). There was no difference in the need for additional intervention of uterotonics between the two groups. There were however, higher incidences of shivering and pyrexia among those that received misoprostol compared with the oxytocin group. Conclusion Rectal misoprostol is as effective and safe as oxytocin when used as an adjunctive uterotonic in preventing primary post-partum haemorrhage in patients with risk factors for uterine atony after active management of third stage of labour.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 82%

A prospective study to compare the effectiveness of adjunctive rectal misoprostol or oxytocin titration in the prevention of primary post-partum haemorrhage in at risk patients

et al. 2019

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“…Elbourrne et al 13 reported significant reduction of the amount of blood loss when prophylactic administration of uterotonic agents during the third stage of labor. Similarly Badejoko et al 14 reported dramatic effect of rectal misoprostol (600 lg) in prevention of PPH comparable with oxytocin infusion.…”

Section: Discussionmentioning

confidence: 95%

Postpartum hemorrhage is related to the hemoglobin levels at labor: Observational study

Frass

2015

Alexandria Journal of Medicine

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Background: Anemia in pregnancy is common and linked to postpartum hemorrhage in terms of uterine atony. The more severe the anemia, the more likely the greater blood loss and adverse outcome. The aim of this study was to examine the association between anemic women at labor and postpartum hemorrhage (PPH) during emergency cesarean delivery and to assess the hemoglobin (Hb) values at which the emergency hysterectomy is needed. Methods and patients: A cross-sectional study was carried out between (Aug. 1st 2012 and Jul. 30th 2013) at Al Thawra General hospital. Fifty-three cases were included in the study. Results: Postpartum hemorrhage was developed in 53 women (29.1%). Out of 53 women, 21 cases (39.6%) had severe uterine atony and required emergency hysterectomy and the remaining 32 cases (60.37%) responded to the conservative measures (p 0.03). Most of the hysterectomized women 80.75% (17/21) had Hb levels 6 7 versus 12.5% of the nonhysterectomized patients [OR 29.75;; p < 0.01]. There was a strong correlation between low Hb levels and blood loss [r = À.619; p < 0.00]. Conclusion: Our study supports the association between anemia (Hb < 10) and the risk of PPH. We also provide evidence of the association between severe anemia and emergency hysterectomy. ª 2014 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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“…Recently, Kessous et al ( 9 ) reported that bleeding accounted for 70% of indications for relaparotomy. Bleeding secondary to uterine atony is preventable by adopting active management of the third stage of labor in women with identifiable risk factors for uterine atony by either rectal misoprostol or oxytocin infusion ( 10 ). Intra-abdominal bleeding after CS depends on the skill and the experience of the operator and the surgical technique used, such factors would be difficult to discern in the current study, because this essential parameter was not evaluated.…”

Section: Discussionmentioning

confidence: 99%

Re-laparotomy After Cesarean Section: Risk, Indications and Management Options

Raagab¹,

Mesbah²,

Brakat³

et al. 2014

Med Arh

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Aim:To identify risks, indications and outcomes for relaparotomy after cesarean delivery.Methods:A prospective case-controlled study conducted at Mansoura University Hospital, Egypt from 2009 to 2012. Each case was matched randomly to 2 cases that had delivered by cesarean section during the same period and did not undergo repeated surgical intervention. Information's on indications were obtained to gather information's on risks factors.Results:relaparotomy complicated 1.04 %(n= 26) of the total number of the cesarean section (CS) (n=2500). The principal indications for relaparotomy were internal bleeding (Intra-abdominal bleeding in 41.7% (n=10); rectus sheath hematoma in 29.2% (n=7) and uncontrolled postpartum hemorrhage (PPH) in 29.2 %(n=7) of cases, followed by infections in 7.7% (n=2) of cases. Resulting in 11.5 %(n=3) maternal death. Predictors for relaparotomy after cesarean delivery from univariate logistic model, placenta previa (OR=6.898, 95% CI=1.867- 25.4, P=.004), fetal weight greater than 4 kg (OR=6.409, 95% CI=1.444-28.44,. 015). Previous cesarean section and parity were not a risk for re-laparotomy.Conclusion:In this study, the incidence of relaparotomy after cesarean delivery was very high (1.04%). Associated with high maternal mortality (11.5%). The main predictors were placenta previa and fetal macrosomia.

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Adjunctive rectal misoprostol versus oxytocin infusion for prevention of postpartum hemorrhage in women at risk: A randomized controlled trial

Cited by 18 publications

References 23 publications

A prospective study to compare the effectiveness of adjunctive rectal misoprostol or oxytocin titration in the prevention of primary post-partum haemorrhage in at risk patients

A prospective study to compare the effectiveness of adjunctive rectal misoprostol or oxytocin titration in the prevention of primary post-partum haemorrhage in at risk patients

Postpartum hemorrhage is related to the hemoglobin levels at labor: Observational study

Re-laparotomy After Cesarean Section: Risk, Indications and Management Options

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