“…This outcome is not hard to understand. Biochemistry and organic chemistry are traditionally difficult courses for nonmajors (4,11). Understanding monosaccharide isomers poses specific challenges: (i) an understanding of the underlying organic and general chemistry principles; (ii) a need for skills to infer three-dimensional structures from two-dimensional diagrams; (iii) motivating oneself to master topics of a very abstract and symbolic nature (12).…”