“…109 Many formal methods for estimating the amount of publication bias in a systematic review, and its effect on the conclusions of the review, have been published. 65,257,265,295,313,326,340,352 One simple method is to calculate the Rosenthal "fail-safe N," which is the number of unpublished studies with a null effect that would need to be added to a metaanalysis to render a treatment effect estimate nonsignificant. 277 This method assumes that unpublished trials would, on average, show a null effect for the experimental treatment.…”