Adjustment of the main biosynthesis modules to enhance the production of l‐homoserine in Escherichia coli W3110
Kun Niu,
Rui Zheng,
Miao Zhang
et al.
Abstract:Abstractl‐homoserine is an important platform compound of many valuable products. Construction of microbial cell factory for l‐homoserine production from glucose has attracted a great deal of attention. In this study, l‐homoserine biosynthesis pathway was divided into three modules, the glucose uptake and upstream pathway, the downstream pathway, and the energy supply module. Metabolomics of the chassis strain HS indicated that the supply of ATP was inadequate, therefore, the energy supply module was firstly m… Show more
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