Adjuvant activity of glucosaminylmuramyldipeptide and prospects of its use for the treatment and prevention of infectious diseases

Abstract

The purpose of the review was to analyze the literature data on the effect of glucosominylmuramyldipeptide on factors of innate and adaptive immunity in the treatment and prevention of various infectious diseases. The purpose of the review was to examine studies conducted over the past 20 years concerning the use of GMDP for the treatment and prevention of infectious diseases of various etiologies. The literature was searched using databases such as RSCI, eLibrary, MedLine. The following search words were used: muramyldipeptide, muramyldipeptide mechanism of action, glucosominylmuramyldipeptide for the treatment of infectious diseases, glucosominylmuramyldipeptide for the prevention of infectious diseases, glucosominylmuramyldipeptide as an adjuvant. GMDP is an activator of innate and acquired immunity, strengthens the body's protection against viral, bacterial and fungal infections, and also has an adjuvant effect in the development of a post-vaccination immune response, which determines the prospects for its further use to improve treatment regimens and specific prevention of various infectious diseases.