Adjuvant chemotherapy improves overall survival in patients with localized upper tract urothelial carcinoma harboring pathologic vascular invasion: a propensity score-matched analysis of multi-institutional cohort

Platinum-based adjuvant chemotherapy for upper tract urothelial carcinoma: a change of paradigm? A meta-analysis of aggregate data

“…We selected four retrospectives reporting OS for a total of 2056 patients who underwent surgery for UTUCs [19,21,22,26]. Although the pooled HR favored the administration of platinum-based AC, the benefit in OS was not statistically significant (pooled HR 0.80; 95% CI, 0.51–1.26) with considerable heterogeneity ( I 2 = 50.38%) (Fig.…”

“…We preferred to perform the analysis in a broader population because of the substantial differences in the definition of high-risk relapsed disease among studies considered. In addition, we included two recently published retrospective studies and the latest data from the RCT POUT trial [6,26,37]. The characteristics of the previous meta-analysis and the present study are outlined in Table 2.…”

“…Of the 53 reports were retrieved for full-text evaluation. Only 16 studies met the inclusion criteria and were included in this systematic review [6,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Table 1 showed the characteristics of the included studies.…”

“…Risk of bias were moderate in 8 studies [18][19][20][21][22]24,26,27] and low in 7 studies [13][14][15][16][17]23,25]. The one RCT scored 3 in the Jadad scale [6] (Supplementary Materials Table S1, S2, Supplemental digital content 1, http://links.lww.…”

“…As already described, we performed a post hoc analysis including five additional studies reporting OS with estimated HRs from Kaplan-Meier curves [14][15][16]20,23]. A total of 9 retrospective studies were considered [14][15][16][19][20][21][22][23]26] including 4943 patients. In overall population, the administration of platinum-based chemotherapy resulted in modest OS benefit with a pooled HR 0.75 (95% CI, 0.57-0.99) with a high level of heterogeneity (I 2 = 63.94%) (Fig.…”