Adjuvant Chemotherapy versus Chemotherapy plus Pelvic Irradiation for High-Risk Cervical Cancer Patients after Radical Hysterectomy and Pelvic Lymphadenectomy (RH-PLND): A Randomized Phase III Trial

Analysis of Prognostic Factors Affecting the Outcome of Stage IB-IIB Cervical Cancer Treated by Radical Hysterectomy and Pelvic Lymphadenectomy

“…21,22 It was controversial whether there was survival benefit in patients receiving postoperative chemotherapy plus radiotherapy with pathologic risk factors. 13 In our study, there was no significant difference in both 3-year DFS (P = 0.984) and OS (P = 0.646) rates between the patients with adjuvant therapy and patients without adjuvant therapy. We consider that this inconsistent result was possibly because of the percentage of patients possessing the 1 or 2 risk factors in the adjuvant therapy group (67/188, 35.64%) was higher than that of in the nonadjuvant therapy (7/87, 8.05%).…”

“…Chemotherapy plus radiotherapy was performed with the combination of periodically sequential chemotherapy and radiotherapy according to the standard. 13 Disease-free survival (DFS) was defined as the time from the date of operation to local failure, systemic failure, or death resulting from any causes, whichever occurred first. Overall survival (OS) was defined as the time from the date of operation to death resulting from any causes.…”

Postoperative adjuvant therapy in early invasive cervical cancer patients with histopathologic high-risk factors

“…Among the histopathologic high-risk factors, lymph node metastasis has been widely accepted as a major factor that is closely linked to the poor treatment outcome following surgery. Many investigators have reported worse treatment outcomes in groups with macroscopic lymph node metastasis, bilaterally involved nodes, multiple positive nodes (2 or more), or positive common iliac and para-aortic lymph node in comparison with microscopic, unilateral, a single positive node, or a positive lymph node below the level of the common iliac (4,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) . In this study, we have compared the treatment outcomes for macroscopic and microscopic nodal involvement when treated with the different postoperative adjuvant modalities.…”

Die adjuvante Chemotherapie des Zervixkarzinoms - Ergebnisse einer Phase II-Studie

“…Eine kleinere, randomisierte Studie wurde von Curtin et al publiziert. Es wurde eine adjuvante Chemotherapie mit einer postoperativen Radiochemotherapie an 89 Patientinnen mit Stadium I B oder II A verglichen [7]. Der Vorteil einer Hinzunahme der Strahlentherapie als weitere lokale Maû-nahme konnte nicht gezeigt werden, die Anzahl der Lokalrezidive war auch in der Hochrisikogruppe in beiden Armen gleich.…”