Adjuvant Chemotherapy with Doxorubicin (Adriamycin) and 5–Fluorouracil in T3, NX, MO Bladder Cancer Treated with Radiotherapy

Abstract

Radical radiotherapy alone has been compared with radical radiotherapy followed by chemotherapy using doxorubicin (Adriamycin) and 5-fluorouracil in a randomised prospective study on 129 patients presenting with T3, NX, MO transitional cell carcinoma of the bladder. One hundred and ten patients were evaluable with a minimum follow-up of 2 years. The addition of this form of chemotherapy did not appear to influence the survival rate or the proportion of patients free from tumour. It cannot be recommended for routine use in the primary treatment of infiltrating bladder cancer.

Cisplatin plus Radiotherapy in Bladder Cancer

“…These figures correspond well with our own results (SAUER et al 1988). The combination of irradiation and cisplatin seems to be superior to a combination of irradiation with other active drugs such as 5-fluorouracil or adriamycin (CROSS et al 1976;RICHARDS et al 1983;ROTMAN et a1.1987).…”

Neoadjuvant Chemotherapy with Cisplatin and Methotrexate in Patients with Muscle-Invasive Bladder Tumours

“…Two randomized trials that assessed the role of adjuvant chemotherapy after radial radiotherapy have been reported (33,34). The compliance was poor because patients were debilitated by radiotherapy.…”

Stellenwert der systemische Chemotherapie des Harnblasenkarzinoms

“…In den letzten 25 Jahren wurde in zahlreichen randomisierten Studien eine lokale Therapie mit adjuvanter Chemotherapie gegenüber einer alleinigen lokalen Therapie verglichen [19,20,21,22,23,24,25], (. Tab.…”