Adjuvant combined paclitaxel and carboplatin chemotherapy for glassy cell carcinoma of the uterine cervix: Report of three cases with clinicopathological analysis

Abstract

Glassy cell carcinoma of the uterine cervix (GCC) is a rare form of cervical carcinoma that is characterized by aggressiveness and poor prognosis. We reviewed a variety of clinicopathological features, treatment strategies, and outcomes in three women with GCC. The three patients were successfully treated by radical hysterectomy with pelvic/para-aortic lymphadenectomy. The patients had stage Ib1, stage IIa, and stage Ib2 tumors without lymph node metastases. A 44-year-old woman with stage Ib1 tumor did not undergo adjuvant chemotherapy or radiation therapy. She had recurrent pelvic tumors 12 months after surgery, and died 6 months after the recurrent disease. The histological findings of her cervix, which were different from the other two patients, did not show the marked infiltration of eosinophils. The other two patients with stage Ib2 and IIa tumors underwent adjuvant chemotherapy with paclitaxel and carboplatin, and had disease-free survival for 4.5 and 9 years. We think that all patients with GCC of stage Ib1 or more should undergo adjuvant chemotherapy of paclitaxel and carboplatin or other adjuvant therapies.

Identification of Displaced Endometrial Glands and Embryonic Duct Remnants in Female Fetal Reproductive Tract: Possible Pathogenetic Role in Endometriotic and Pelvic Neoplastic Processes

“…The findings of embryonic ducts spread in broad ligaments and under the fallopian tube serosa in our series could be related to studies describing occurrence of endometriomas as well as neoplasms of a Müllerian origin in these locations (Zacharia and O’Neill, 2006; Handa et al, 2007; Wei et al, 2011). Finally, the aberrant and consistent expression of alpha-1-fetoprotein revealed in the embryonic ducts in two fetuses is in accordance with other studies that reported de novo expression of this protein in ovarian malignancy arising from endometriosis (Horiuchi et al, 1998; Certin et al, 2007; Takahashi et al, 2011). …”

Carcinomatous meningitis from recurrent glassy cell carcinoma of the uterine cervix—A case report

“…Its prognosis is poor due to its resistance to radiotherapy and chemotherapy, rapid progression, and recurrence tendency. [11][12][13] Although there have been reports of successful chemotherapy and radiotherapy, [13][14][15] surgery and postoperative CCRT were chosen in this case because of the difficulty of intracavitary radiotherapy; subsequently, a disease-free-interval of 9 months was achieved. Thus, treatment should be decided based on each case due to the lack of an exclusive one.…”

Carcinoma de colo uterino tipo glassy cell

“…A principal característica anatomopatológica do câncer do tipo glassy cell é a quantidade moderada de citoplasma granular pálido com aspecto de vidro moído, núcleos localizados centralmente com nucléolo proeminente, membranas celulares distintas e proeminente infiltração de eosinófilos no estroma. 1 Receptores de estrogênio e progesterona foram encontrados em tumores do tipo glassy cell, sugerindo que este tumor pode ser responsivo a esses hormônios. 9 Kato e colaboradores 4 sugerem forte associação do tumor tipo glassy cell com o HPV 18, que poderia induzir a aparência "vítrea" do citoplasma possivelmente por induzir a diferenciação escamosa e glandular bifásica.…”

“…Foi descrito pela primeira vez em 1956 por Cherry e Gucksmann. 1 A idade média de incidência é de cerca de 10 anos menor do que a média de pacientes com carcinomas de células escamosas e de adenocarcinomas do colo do útero, 2 com pico de incidência entre a terceira e quarta décadas. 3 Seu comportamento clínico é caracterizado pela agressividade com rápido crescimento e progressão, metástases precoces e fraca resposta à radioterapia e cirurgia.…”