Adjuvant cytotoxic liver perfusion for colorectal cancer

Taylor, Imogen; Rowling, J. Thompson; West, Christopher R.

doi:10.1002/bjs.1800661202

Cited by 103 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5.-FU administration. This observation provides a possible explanation for the clinical trial results of Taylor et al (1979), who reported a marked benefit for the prevention of recurrences with adjuvant treatment by i.p.v. 5-FU.…”

Section: Pharmacokineticsmentioning

confidence: 66%

“…Use of the portal vein appears advisable for small liver metastases (Ackerman et al, 1969). Immediate post-surgery infusion of 5-flourouracil (5-FU) in the portal vein has recently been shown to significantly reduce the rate of disease recurrence at two years for Dukes' C lesions (Taylor et al, 1979). Ensminger et al (1978) have published detailed pharmacokinetic data concerning the i.a.h.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation

Boublil¹,

Milano²,

Khater³

et al. 1985

Br J Cancer

View full text Add to dashboard Cite

Eighteen patients with liver metastasis or locoregional recurrence of colon carcinoma received locoregional treatment by continuous 5-day infusions of 5-FU. 5-FU blood levels were measured by HPLC every day of the cycle at 8 am and 5 pm for a total of 87 cycles. Twelve patients were given the drug by an intra-arterial hepatic (i.a.h.) route, 3 by the portal vein (i.p.v.) and 3 by an intra-arterial pelvic (i.a.p.) route. These three routes were compared in respect of their relative pre-systemic drug uptake and the effect of dose escalation. Both the i.a.h. and i.p.v. routes, but not the i.a.p. route, resulted in a significant reduction in AUC 0-105 h compared to the i.v. route at the same dose range. Increasing the dose led to a modification in circulating 5-FU levels proportional to the dose for the i.v. and i.a.p. routes. By contrast, for the i.a.h. and i.p.v. routes, systemic drug delivery was significantly elevated, out of proportion with the dose, indicating a saturable process. For the i.a.h. route, increasing the 5-FU dose from 780 to 1000 mg m-2 day-1 caused a drop in hepatic extraction from 0.93 (0.90-0.95) to 0.44 (0.21-0.66). Liver saturation mechanisms were also evidenced by a mean increase of 2.6 times for the circulating drug level during the second part of the cycle as compared to the first part (P less than 0.001). The evolution of 5-FU AUC 0-105 h as a function of the dose was exponential (r = 0.75, P less than 0.001). Local extraction consecutive to i.a.p. was non-existent, implying that this route of drug administration has no potential advantage over classical i.v. infusion.

show abstract

Section: Pharmacokineticsmentioning

confidence: 66%

mentioning

confidence: 99%

Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation

Boublil¹,

Milano²,

Khater³

et al. 1985

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Whereas a longer course might have revealed some effect, the intention of this study was to examine the effect of a short course equivalent to that used in adjuvant liver perfusion in man (Taylor et al 1979). From this viewpoint, any concern that such therapy might promote further large bowel neoplasms would thus seem to be groundless.…”

Section: Discussionmentioning

confidence: 99%

“…Intrahepatic infusion of heparin and 5-fluorouracil (5FU) given peroperatively and for one week postoperatively to patients undergoing curative surgery for large bowel cancer has been claimed to prolong survival (Taylor et al 1979).…”

Section: Introductionmentioning

confidence: 99%

Experimental Colon Neoplasia Enhanced by Extract of Sperm (Protamine)

Quill

Dudley

1984

J R Soc Med

View full text Add to dashboard Cite

An experimental study of colorectal tumorigenesis in inbred rats given the potent carcinogen dimethylhydrazine has shown that protamine, given before any tumours had developed, significantly enhanced the development of large bowel tumours (100% incidence). Those animals having no adjuvant therapy or who received either heparin or 5-fluorouracil (alone or in combination) had an approximate 50% incidence of such tumours.

show abstract

“…Thus, effective adjuvant treatment is essential to prevent liver metastasis. Many efforts have been attempted in this setting, adjuvant portal venous chemotherapy is an option to prevent the development of colorectal liver metastasis with some encouraging results (Taylor et al, 1979). Taylor et al further suggested that 5-fluorouracil (5-FU) could be effective as an adjuvant therapy if infused via the portal vein (PVI) (Taylor et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer

Liu²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To explore the effect of portal vein chemotherapy on liver metastasis after surgical resection of colorectal cancer. Methods: Patients fulfilling the eligibility criteria were assigned to receive either surgery plus 1-week continuous infusion of 5-FU (study group) or surgery alone (observational group). Patients in the study group received portal vein chemotherapy, whereby 5-FU (1000 mg/d) and heparin (5000 IU/d) infusion was initiated from the day of surgery and lasted for 7 consecutive days. Liver metastasis was monitored during five years follow-up postoperatively. Results: Sixty four patients were recruited and assigned to the study group (12 with colon and 20 with rectal cancer) or the control group (10 with colon and 22 with rectal cancer). Liver metastasis rate was 12.5% in study and 25.0% in observational group, the difference being significant (P<0.01). Conclusion: Portal vein chemotherapy could be an effective treatment in preventing liver metastasis after surgical resection of colorectal cancer.

show abstract

Adjuvant cytotoxic liver perfusion for colorectal cancer

Cited by 103 publications

References 21 publications

Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation

Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation

Experimental Colon Neoplasia Enhanced by Extract of Sperm (Protamine)

Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer

Contact Info

Product

Resources

About