The present experiment was carried out in order to evaluate the potential\ud
adjuvant effect of bovine lactoferrin (bLF) in modulating the specific antibody (Ab)\ud
response to an exogenous protein, the human-c-globulins (HcG), injected intraperitoneally\ud
in rainbow trout Oncorhynchus mykiss (Walbaum 1792). Moreover, serum natural antibody\ud
(NatAb) level, serum total immunoglobulin (IgM) level and specific Ab response to\ud
bLF were also analysed. Experimental data showed that HcG is able to stimulate a specific\ud
Ab response when not adjuvanted with Freund’s complete adjuvant (FCA), whereas bLF\ud
induces a specific Ab response only if adjuvanted with FCA. Statistical analyses revealed\ud
that neither bLF or FCA administered singly had significant effects on serum NatAb and\ud
IgM levels, whereas the specific immune response observed against HcG when adjuvanted\ud
with bLF was comparable to that achieved when FCA was used as the adjuvant. These\ud
results provide evidence of the potential for bLF to be used as an adjuvant for salmonids