Adjuvant effects of bacterium-like particles in the intranasal vaccination of chickens against Newcastle disease

Yang, Rui; Zhang, Shubo; Yu, Yue; Hong, Xuemin; Wang, Dan; Jiang, Yanlong; Yang, Wentao; Huang, Haibin; Shi, Chunwei; Zeng, Yan; Wang, Nan; Cao, Xin; Wang, Jianzhong; Wang, Chunfeng

doi:10.1016/j.vetmic.2021.109144

Cited by 8 publications

(9 citation statements)

References 46 publications

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“…Bacterium-like particles (BLPs) are bioinspired/ biomimetic particles that are used for cargo delivery. 37,38 We loaded AIE PSs within BLPs and then immobilized them on plasma-functionalized surfaces. BLPs have intact peptidoglycan coverings, although their DNA and proteins are degraded.…”

Section: Introductionmentioning

confidence: 99%

“…The AIE PS has been integrated with various particles including fluorescent polymerosomes for cutting-edge applications. , To harness the photodynamic potential of ASCP-TPA for advanced biomedical applications, we made use of biomimetic nanomedicine to develop hybrid materials with minimal immunogenicity. Bacterium-like particles (BLPs) are bioinspired/biomimetic particles that are used for cargo delivery. , We loaded AIE PSs within BLPs and then immobilized them on plasma-functionalized surfaces. BLPs have intact peptidoglycan coverings, although their DNA and proteins are degraded.…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic Bacterium-like Particles Loaded with Aggregation-Induced Emission Photosensitizers as Plasma Coatings for Implant-Associated Infections

Wang,

Ninan,

Nguyen

et al. 2024

ACS Appl. Mater. Interfaces

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Developing novel antibacterial strategies has become an urgent requisite to overcome the increasing pervasiveness of antimicrobial-resistant bacteria and the advent of biofilms. Aggregation-induced emission-based photosensitizers (AIE PSs) are promising candidates due to their unique photodynamic and photothermal properties. Bioengineering structure-inherent AIE PSs for developing thin film coatings is still an unexplored area in the field of nanoscience. We have adopted a synergistic approach combining plasma technology and AIE PS-based photodynamic therapy to develop coatings that can eradicate bacterial infections. Here, we loaded AIE PSs within biomimetic bacterium-like particles derived from a probiotic strain, Lactobacillus fermentum. These hybrid conjugates are then immobilized on polyoxazoline-coated substrates to develop a bioinspired coating to fight against implant-associated infections. These coatings could selectively kill Gram-positive and Gram-negative bacteria, but not damage mammalian cells. The mechanistic studies revealed that the coatings can generate reactive oxygen species that can rupture the bacterial cell membranes. The mRNA gene expression of proinflammatory cytokines confirmed that they can modulate infection-related immune responses. Thus, this nature-inspired design has opened a new avenue for the fabrication of a next-generation antibacterial coating to reduce infections and associated burdens.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomimetic Bacterium-like Particles Loaded with Aggregation-Induced Emission Photosensitizers as Plasma Coatings for Implant-Associated Infections

Wang,

Ninan,

Nguyen

et al. 2024

ACS Appl. Mater. Interfaces

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“…Newcastle disease is a serious viral poultry disease caused by an enveloped virus from the Paramyxoviridae family, subfamily Avulavirinae and genus Avulavirus (Yang et al, 2021). NDV is a negative sense non segmented single-stranded RNA virus (Shaw & Palese, 2013).…”

Section: Introductionmentioning

confidence: 99%

Pathological and Epidemiological Study on Newcastle Disease in Broiler Chicken Farms in Egypt between 2021-2022.

Khair,

El Ballal,

El-Shemy

et al. 2024

Journal of Current Veterinary Research

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Newcastle disease virus (NDV) is an economic threat to the poultry industry worldwide. In this study, we aimed to investigate the incidence of NDV in the vaccinated Egyptian poultry flocks through histopathological and molecular investigation. One hundred and nine broiler chicken flocks were examined during the period from January 2021 to December 2022from seven different Egyptian governorates (El-Beheira, El-Fayoum, El-Gizza, El-Gharbia, El-Menofia, El-Qalyubia, and El-Sharqia). History, clinical signs, and gross examination of the affected flocks were recorded. Brain, nostril, trachea, lung, heart, proventriculus, duodenum, liver, pancreas, thymus, spleen, bursa, cecal tonsil, and kidney were collected for histopathological examination and only the tracheal tissues for Real-time polymerase chain reaction (RT-PCR). The most observed gross lesion in the examined samples was the hemorrhage in the proventriculus. Histopathologically, cerebral spongiosis, brain vasculitis, rhinitis, tracheitis, pneumonia, pericarditis, hemorrhage in the proventriculus, enteritis, perihepatitis, necrotizing pancreatitis, lymphoid depletion of the immune organs, and proliferation of lymphoid tissue in kidney. Furthermore, lymphoid proliferation was detected in the lung, proventriculus, and liver. From the examined samples, only forty-three samples were found to be positive by RT-PCR, which represented 39.5% of the total samples. From our results, we can conclude that NDV circulates in the vaccinated broiler flocks in Egypt. Therefore, reconsidering the immune status, vaccination programs, and surveillance of newly emerged strains are essential to reduce the incidence of ND in Egypt.

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“…[ 15 ] Lactococcus lactis ( L. lactis ) is a harmless gram‐positive bacteria, widely used in the food industry and granted generally recognised as safe status by the US Food and Drug Administration, the excellent biosafety of which makes it an ideal candidate for use in vaccines. As a conserved microbe‐associated molecular pattern of gram‐positive bacteria, peptidoglycan is recognized by innate immune cells, and the triggered signaling cascade causes the production of pro‐inflammatory cytokines and activated intrinsic immune cells capable of forming adaptive B‐cell and T‐cell‐mediated immune responses, [ 16 ] all of which have great potential in vaccine development. Vaccines prepared using BLPs induce a robust local and systemic immune response, and this immune response is protective against infection by specific pathogens, including viruses, bacteria, and parasites.…”

Section: Introductionmentioning

confidence: 99%

Genetically engineered bacterial‐like particles induced specific cellular and humoral immunity as effective tick‐borne encephalitis virus vaccine

Zhang

Jin

et al. 2023

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Tick-borne encephalitis (TBE) is a natural focal disease with fatal encephalitis induced by tick-borne encephalitis virus (TBEV), seriously threatening human and public health. Protection of TBE depends on vaccination with inactivated vaccine, which requires high cost and multiple immunizations. Here, we construct genetically engineered bacterial-like particles (BLPs) as an effective TBEV vaccine with simplified immunizations and improved immune efficacy. The TBEV BLPs involve the combination of the gram-positive enhancer matrix from Lactococcus lactis, and TBEV envelope (E) protein expressed by genetically engineered recombinant baculovirus. The prepared TBEV BLPs can effectively stimulate the activation of dendritic cells to present the TBEV E proteins to T and B cells, leading to strong and durable cellular and humoral immune responses in mice. Surprisingly, the serum levels of specific IgG antibodies in mice remain about 10 6 at 6 months after the secondary immunization. Overall, the TBEV BLPs can be used as a potent vaccine candidate, laying the foundation for developing novel TBEV genetically engineered vaccines.

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Adjuvant effects of bacterium-like particles in the intranasal vaccination of chickens against Newcastle disease

Cited by 8 publications

References 46 publications

Biomimetic Bacterium-like Particles Loaded with Aggregation-Induced Emission Photosensitizers as Plasma Coatings for Implant-Associated Infections

Biomimetic Bacterium-like Particles Loaded with Aggregation-Induced Emission Photosensitizers as Plasma Coatings for Implant-Associated Infections

Pathological and Epidemiological Study on Newcastle Disease in Broiler Chicken Farms in Egypt between 2021-2022.

Genetically engineered bacterial‐like particles induced specific cellular and humoral immunity as effective tick‐borne encephalitis virus vaccine

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