Adjuvant hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases

Curley, Steven A.; Roh, Mark S.; Chase, Judy L.; Höhn, D.

doi:10.1016/s0002-9610(05)80691-9

Cited by 87 publications

(40 citation statements)

References 15 publications

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“…A recent single-arm study using adjuvant HAI after liver resection provides further encouragement for definitive trials in this area. 33 At the Memorial Sloan-Kettering Cancer Center, we are currently randomizing patients after complete tumor resection to receive or not receive adjuvant HAI chemotherapy in combination with systemic chemotherapy.…”

Section: Adjuvant Therapymentioning

confidence: 99%

“…However, this method of delivery has been associated with a high incidence of gastrointestinal complications due to perfusion of the stomach or duodenum by branches of the hepatic artery. This problem can be remedied by using surgically placed ports, 33 because small arteries from the hepatic artery to the gastrointestinal tract can be meticulously ligated during the surgical procedure. These arterial ports, however, are associated with frequent thrombosis and occlusion and have the inconvenience of requiring an external pump.…”

Section: Regional Infusional Therapymentioning

confidence: 99%

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Surgical treatment of colorectal metastases to the liver

Fong

Blumgart

Cohen

1995

CA: A Cancer Journal for Clinicians

124

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Section: Adjuvant Therapymentioning

confidence: 99%

Section: Regional Infusional Therapymentioning

confidence: 99%

Surgical treatment of colorectal metastases to the liver

Fong

Blumgart

Cohen

1995

CA: A Cancer Journal for Clinicians

124

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“…Curley, Roh et al (1992) have reported that recurrence in the RL occurred in nine (50%) of 18 patients treated with AIC, but also found that the recurrence rate was significantly lower than that in patients not undergoing AIC. Kinoshita, Ozaki et al (1997) have reported that the 3-year and 5-year survival rates for overall 69 patients with liver metastasis from colorectal cancer were 16.2% and 6.8%, but were 55.6% and 29.6%, respectively, for 14 of these patients who underwent ANNALS OF Cancer Research and Therapy liver resection with AIC.…”

Section: Discussionmentioning

confidence: 93%

Prognostic Factors in the Hepatic Metastasis From Colorectal Cancer After Hepatectomy and Preventive Arterial Infusion Chemotherapy

Aoki

Kasuya

Tsuchida

et al. 2001

ACRT

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To study the prognostic factors in patients with hepatic metastasis from colorectal cancer after hepatectomy and preventive arterial infusion chemotherapy (AIC). We examined outcomes in 42 patients treated with preventive AIC and evaluated possible prognostic factors by investigating clinicopathological variables with double staining with hematoxylin-eosin and Victoria blue for hepatic metastasis. The cumulative survival rates of patients with primary lesions smaller than 5cm were significantly greater than those of patients with primary lesions 5cm or larger in diameter. However, the site of primary lesion, Dukes' classification, and vessel invasion of the primary lesion did not affect survival. Although the cumulative survival rates of patients with vessel invasion in hepatic metastases were significantly lower than those of patients without vessel invasion, survival did not differ significantly on the basis of other variables. In addition, the incidence of recurrence was significantly higher in patients with vessel invasion of the primary lesion or lymph node metastasis than in other patients. These results suggest that vessel invasion of hepatic metastasis and that of primary lesions is significantly correlated with cumulative survival rates and recurrence in the remnant liver and strongly indicate an increased risk of recurrence.

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“…Hepatic arterial, as well as portal venous, infusion has been studied with a variety of chemotherapeutic regimens. [103][104][105] Only one randomized trial has been performed examining the role of regional adjuvant therapy. 106 Although the patient number was small, none of the 5 patients with adjuvant hepatic arterial infusion (HAI) therapy developed hepatic recurrence.…”

Section: Results Of Liver Resection For Colorectal Metastasesmentioning

confidence: 99%

Management of hepatic metastases

Choti

Bulkley

1999

Liver Transpl

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Although the liver is the most common site of metastatic disease from a variety of tumor types, isolated hepatic metastases most commonly occur from colorectal cancer and, less frequently, from neuroendocrine tumors, gastrointestinal sarcoma, ocular melanoma, and others. Complete evaluation of the extent of metastatic disease, both intrahepatically and extrahepatically, is important before considering treatment options. Based on a preponderance of uncontrolled studies for hepatic metastatic colorectal carcinoma, surgical resection offers the only potential for cure of selected patients with completely resected disease, with 5-year survival rates of 25% to 46%. Systemic and hepatic arterial infusion chemotherapy may be useful treatment options in patients with unresectable disease and possibly as an adjuvant treatment after liver resection. Other techniques of local tumor ablation, including cryotherapy and radiofrequency ablation, although promising, remain unproved. Management of hepatic metastases from neuroendocrine tumors and other noncolorectal primary tumors should be individualized based on the patient's clinical course, extent of disease, and symptoms. Copyright 1999 by the American Association for the Study of Liver DiseasesA s many as 50% of the patients with a primary malignancy will eventually develop metastases in the liver, a percentage greater than for any other organ, including the lung. Although primary tumors that drain principally into the portal circulation are more likely than others to develop hepatic metastases, many tumors arising in other sites, such as the breast and lung, also commonly develop hepatic metastases. Although the liver represents a common site of spread from many of these solid tumors, isolated hepatic metastases most commonly occur from colorectal and neuroendocrine tumors. Other less common malignancies also can metastasize predominantly to the liver. For most other solid malignancies, the pattern of metastatic disease is most often that of generalized dissemination. Colorectal MetastasesCancer of the colon and rectum is the third most commonly diagnosed cancer in the United States. An estimated 131,600 new cases will have been discovered in 1998, comprising 11% of new cancer diagnoses. 1 An estimated 56,500 deaths will occur from colorectal cancer that year, comprising 10% of all cancer deaths. 1 Although mortality from largebowel cancer has been improving over the past 30 years, largely because of improvements in early detection, diagnosis, and treatment, approximately 50% of the patients with colorectal cancer eventually die of their neoplastic disease. 1 The liver is the most commonly involved organ in patients with metastatic colorectal cancer. Approximately 20% of these patients have clinically recognizable liver metastases at the time of their primary diagnosis. 1,2 After resection of a primary colorectal cancer in the absence of apparent metastatic disease, approximately 50% of the patients will subsequently manifest metastatic liver disease. Given these figures,...

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Adjuvant hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases

Cited by 87 publications

References 15 publications

Surgical treatment of colorectal metastases to the liver

Surgical treatment of colorectal metastases to the liver

Prognostic Factors in the Hepatic Metastasis From Colorectal Cancer After Hepatectomy and Preventive Arterial Infusion Chemotherapy

Management of hepatic metastases

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