Adjuvant-Induced Arthritis in Guinea Pigs

Taranov, Oleg S.; Sn, Yakubitskiy; Ts, Nepomnyashchikh; Ae, Nesterov; Sn, Shchelkunov

doi:10.32607/20758251-2016-8-4-110-117

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…The main pathological characteristics of the RA are synovial cell hyperplasia, infiltration of inflammatory cells, cartilage degeneration, bone erosion and pannus formation that also occurred in AIA rats (Amraei et al., 2015). The histopathological index in the articular structure was confirmed by H&E staining (Taranov et al., 2016). In the present study, no obvious differences were noted among the Marham‐Mafasel , Piroxicam and control groups.…”

Section: Discussionmentioning

confidence: 99%

Marham‐Mafasel decrease joint inflammation and IL‐1β gene expression in rheumatoid arthritis animal model

Majidi

Heidarnejad

Naseri

et al. 2021

Veterinary Medicine & Sci

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Section: Discussionmentioning

confidence: 99%

Marham‐Mafasel decrease joint inflammation and IL‐1β gene expression in rheumatoid arthritis animal model

Majidi

Heidarnejad

Naseri

et al. 2021

Veterinary Medicine & Sci

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“…The animals were injected with 0.1 ml of CFA mixed with phosphate buffer saline in the ratio 1:1 subcutaneously into the right hind paw, while the equivalent volume of normal saline was injected subcutaneously to the control group ( Taranov et al., 2016 ). The NMRs were anaesthetized before injection of CFA and during paw measurements using isoflurane.…”

Section: Methodsmentioning

confidence: 99%

Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)

Thuo

Towett

Kanui

et al. 2022

Heliyon

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The naked mole rat (NMR) is a fossorial rodent that has been observed to have a unique nociceptive system in comparison to others. In this study, we explored on characterization of chronic inflammation in the NMR using Complete Freund's adjuvant (CFA) and investigated the effects of dexamethasone and acetylsalicylic acid on the resulting inflammation. The NMRs were injected with 0.1 ml of CFA subcutaneously in the right hind paw, and an equivalent volume of normal saline was injected to the control group. Swelling of the injected right hind limb was observed within 24 h of injection, which involved the tibiotarsal joint, palmar surface and the digits of the injected paw. Swelling persisted for 6 weeks of experimentation and peaked between day 14 and 21. The resulting inflammation affected the mobility, stance and joint rigidity of CFA treated NMRs in comparison to the control group. Treatment of the chronic phase of the inflammation from the 11 th day with dexamethasone and acetylsalicylic acid showed no statistical significance in paw circumference compared to the control group, other than on a few, negligible occasions. The present data showed that CFA was able to induce chronic inflammation in the NMR, and the NMR could thus be established as a model for chronic inflammation. There is, however, need for more sensitive parameters to evaluate the effects of anti-inflammatory drugs.

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The role of the metabolic status of lymphocytes in the pathogenesis of rheumatoid arthritis

Скупневский¹,

Pukhaeva²,

Badtiev³

et al. 2021

Sovremennaâ revmatologiâ

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Objective: to study in dynamics metabolic changes in lymphocytes on the model of adjuvant-induced rheumatoid arthritis (RA) in warm-blooded animals.Material and methods. The RA model was elicited by administering Freund's complete adjuvant (AF) to male Wistar rats. Lymphocyte metabolism was corrected with a mixture of citric and succinic acids, which was injected for 4 weeks (at doses of 17 and 88 mg/kg body weight) from the first day of model formation. Animals of the control group were injected subcutaneously with isotonic sodium chloride solution. The total number of leukocytes, the size of lymphocytes and the activity of lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) in these cells were determined. Changes in the musculoskeletal system were assessed radiographically and actometrically in the «open field» model.Results and discussion. In the first 2 weeks of the experiment in the model group, an increase in the level of leukocytes by 65% compared to the control (p=0.002) was noted, an increase in the activity of lymphocytes SDH by 51% and a decrease in the total («horizontal») mobility of animals by 30% were also revealed. Subsequently, the level of leukocytes decreased by 25%, the activity of LDH and SDH – by 38%, the radius of lymphocytes – by 14% (p<0.01). The action of carboxylic acids was dose-dependent: at the maximum dose, no statistically significant differences in the total number of leukocytes, LDH and SDH activity in lymphocytes, as well as their sizes were found between the group with adjuvant- induced RA and the control group.Conclusion. In animals with adjuvant-induced RA, correction of the metabolic status of lymphocytes with a mixture of citric and succinic acids, which are key substrates of the Krebs cycle, led to a decrease in structural damage of musculoskeletal system and, as a consequence, to the maintenance of normal range of motion.

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Adjuvant-Induced Arthritis in Guinea Pigs

Cited by 3 publications

References 11 publications

Marham‐Mafasel decrease joint inflammation and IL‐1β gene expression in rheumatoid arthritis animal model

Marham‐Mafasel decrease joint inflammation and IL‐1β gene expression in rheumatoid arthritis animal model

Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)

The role of the metabolic status of lymphocytes in the pathogenesis of rheumatoid arthritis

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