Adjuvant probiotics improve the eradication effect of triple therapy forHelicobacter pyloriinfection

Abstract

Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates.

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

“…Data coming from our and previous studies show that probiotic supplement either Lactobacillus or Bifidobacterium containing drinking yogurt enhances the H. pylori eradication. This positive result could possibly be explained by probiotics decrease H. pylori load, in spite of antimicrobial resistance, thus improving the efficacy of eradication therapy (Sheu et al, 2006, Du et al, 2012. In additions, as shown in our study, adding probiotics also reduced the side effects of the treatment regimens .…”

Meta-analysis of the efficacy of probiotics inHelicobacter pylorieradication therapy

“…Our results show that there was no significant difference in the pooled indices of the eight studies with Jadad scores ≥ 3, in the 12 studies that used single probiotic preparations, or when the 14 studies were included. There was also no significant difference between studies that used triple therapy regimens lasting Emara et al [15] HpSA, RUT, Histology HpSA, RUT, Histology 4 wk 1 0.00% Non-Boer 6 wk 2 Medeiros et al [16] Culture UBT ≥ 6 wk 0.00% Not reported Song et al [17] RUT, Histology UBT 4 wk 8.50% Non-Boer Du et al [18] RUT, UBT, Pathologic examination UBT 4 wk 2.60% Non-Boer…”

“…However, the Maastricht 4-2012 Consensus Report recommends sequential or concomitant regimens as the best first-line treatments in areas with high rates of clar- [17] (Korea) [18] (China) [19] (Japan) [20] (Iran) [21] (Italy) [24] (Finland) [25] (Turkey) [26] (Korea) [27] (Italy) [28] (Turkey) ithromycin resistance. Other treatment regimens include quadruple therapy and miscellaneous therapy.…”

“…The identified studies were published between 2000 and 2014. The ethnicity in five studies was Asian [17][18][19]23,26] and Caucasian in the remaining studies.…”

“…Eighty-eight studies were excluded after more detailed assessments were made (21 studies were in animals or in vitro, 14 studies were in children, 13 studies did not use a standard triple therapy, 21 were unrelated studies, and 5 studies had no rigorous inclusion criteria), and the remaining 14 studies [15][16][17][18][19][20][21][22][23][24][25][26][27][28] were considered suitable for inclusion in the analysis. A flow diagram of the study selection process is shown in Figure 1.…”