Adjuvant Radiation Therapy for Thoracic Soft Tissue Sarcomas: A Population-Based Analysis

Rehmani, Sadiq; Raad, Wissam; Weber, Joanna F.; Lazarev, Stanislav; Ayub, Adil; Al-Ayoubi, Adnan M.; Bhora, Faiz Y.

doi:10.1016/j.athoracsur.2019.07.075

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Rehmani et al showed that radiotherapy could improve survival in patients with high-grade STS. 37 The present findings confirm that radiotherapy can reduce DM risk in patients with LMS who undergo surgical resection; local radiotherapy can destroy residual lesions, thereby reducing metastasis risk. Additionally, LMS is a chemotherapy-sensitive tumor; the present study showed that systemic chemotherapy has a positive effect on DM control.…”

Section: Discussionsupporting

confidence: 81%

Web-based nomogram to predict postresection risk of distant metastasis in patients with leiomyosarcoma: retrospective analysis of the SEER database and a Chinese cohort

Wei,

Liu,

et al. 2023

J Int Med Res

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Objectives This study investigated risk factors and constructed an online tool to predict distant metastasis (DM) risk in patients with leiomyosarcoma (LMS) after surgical resection. Methods Data regarding patients with LMS who underwent surgical resection between 2010 and 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Data were collected regarding patients with LMS who underwent surgical resection at Tianjin Medical University Cancer Hospital and Institute (TJMUCH) between October 2010 and July 2018. Patients were randomly divided into training and validation sets. Logistic regression analyses were performed; a nomogram was established. The area under the curve (AUC) and calibration curve were used to evaluate the nomogram, which served as the basis for a web-based nomogram. Results This study included 4461 and 76 patients from the SEER database and TJMUCH, respectively. Age, ethnicity, grade, T stage, N stage, radiotherapy, and chemotherapy were associated with DM incidence. C-index values were 0.815 and 0.782 in the SEER and Chinese datasets, respectively; corresponding AUC values were 0.814 and 0.773, respectively. A web-based nomogram ( https://weijunqiang-leimyosarcoma-seer.shinyapps.io/dynnomapp/ ) was established. Conclusions Our web-based nomogram is an accurate and user-friendly tool to predict DM risk in patients with LMS; it can aid clinical decision-making.

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Section: Discussionsupporting

confidence: 81%

Web-based nomogram to predict postresection risk of distant metastasis in patients with leiomyosarcoma: retrospective analysis of the SEER database and a Chinese cohort

Wei,

Liu,

et al. 2023

J Int Med Res

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“…Seven studies reported on overall survival outcomes. Five articles reported no significant survival benefit in those receiving radiotherapy 7,14–17 . Two articles did not report any statistical data 6,13 …”

Section: Resultsmentioning

confidence: 99%

“…There are several limitations to consider in our study. Three of four studies in our meta-analysis were non-randomized, [15][16][17] and given the high degree of clinical heterogeneity there remains a risk of selection bias and confounding. Further, the only randomized trial in our analysis is the only study trending towards favouring the use of radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy versus limb‐sparing surgery alone in low‐grade soft‐tissue sarcoma of the extremity and trunk wall: a systematic review and meta‐analysis

Trieu,

Gong,

Benoit

et al. 2024

ANZ Journal of Surgery

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Current guidelines recommend the use of radiotherapy in the management of intermediate and high‐grade soft‐tissue sarcoma of the extremity and trunk wall. Its use in low‐grade sarcoma is less clear. To date there have been no pooled data analyses regarding its role in this context. Its use is not without complications and therefore must be justified. We aim to assess the oncological impact of radiotherapy versus limb‐sparing surgery alone in this subset of sarcoma. Medline, EMBASE and Cochrane's databases were searched from 1982 to present. Studies on or having a subgroup analysis of low‐grade soft tissue sarcoma, with a radiotherapy and a surgery only arm were included. Outcomes included local recurrence and overall survival. Patients were at least 16 years of age with primary de‐novo sarcoma who had not undergone prior resection or treatment. Those undergoing concomitant therapy were excluded. Data extraction was performed independently by two reviewers. Results were pooled using a random‐effects model and presented as a forest plot. Primary outcome measures included local recurrence and overall survival. Eleven unique studies were included, consisting of two RCTs and nine non‐randomized studies. Overall, there were 12 799 patients. Four studies were included in meta‐analysis and the overall pooled effect showed a limited role of radiotherapy in overall survival outcomes when compared to limb‐sparing surgery alone HR 1.00 [0.83–1.20] P = 0.41. Descriptive analysis suggests there is limited role of radiotherapy in improving local recurrence outcomes. This study suggests there is limited role for radiotherapy versus limb‐sparing surgery alone in low‐grade soft‐tissue sarcoma. These findings strongly suggest there is lack of high‐quality data and that further research must be undertaken prior to forming any strong conclusions regarding the management of low‐grade soft‐tissue sarcoma. Demonstrating a role for radiotherapy may help improve the quality of excisional margins and thus potentiate limb‐sparing surgery.

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Therapy

Mocellin¹

2020

Soft Tissue Tumors

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Adjuvant Radiation Therapy for Thoracic Soft Tissue Sarcomas: A Population-Based Analysis

Cited by 4 publications

References 32 publications

Web-based nomogram to predict postresection risk of distant metastasis in patients with leiomyosarcoma: retrospective analysis of the SEER database and a Chinese cohort

Web-based nomogram to predict postresection risk of distant metastasis in patients with leiomyosarcoma: retrospective analysis of the SEER database and a Chinese cohort

Radiotherapy versus limb‐sparing surgery alone in low‐grade soft‐tissue sarcoma of the extremity and trunk wall: a systematic review and meta‐analysis

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