Adjuvant Radiotherapy in Prostate Cancer Patients Treated with Surgery: The Impact of Age and Tumor Characteristics

Abdollah, Firas; Karakiewicz, Pierre I.; Gandaglia, Giorgio; Dalela, Deepansh; Klett, Dane; Shiffmann, Jonas; Montorsi, Francesco; Briganti, Alberto; Saad, Fred; Graefen, Markus; Peabody, James O.; Menon, Mani; Sun, Maxine

doi:10.1016/j.euf.2015.06.008

Cited by 5 publications

(3 citation statements)

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“…We observed a 3-year BC-RFS of 61.4%, which is comparable to that reported in a systematic review, of 57-64% [25]. Overall, clinical recurrence was noted in 18.2% patients, predominantly in the regional lymph nodes alone (in 47.9% clinically relapsed patients).…”

Section: Discussionsupporting

confidence: 84%

Pathological stage, surgical margin and lymphovascular invasion as prognostic factors after salvage radiotherapy for post-prostatectomy relapsed prostate cancer — outcomes and optimization strategies

Rodrigues

Ferreira

Gonçalves

et al. 2021

Rep Pract Oncol Radiother.

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Section: Discussionsupporting

confidence: 84%

Pathological stage, surgical margin and lymphovascular invasion as prognostic factors after salvage radiotherapy for post-prostatectomy relapsed prostate cancer — outcomes and optimization strategies

Rodrigues

Ferreira

Gonçalves

et al. 2021

Rep Pract Oncol Radiother.

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“…Adjuvant or salvage EBRT is guideline recommended and delivered between 6% and 12% of RP treated patients. 13,14 The use of combi- These differences represent the basis for propensity score matched analyses, that were aimed to maximally reduce potential selection biases related to these baseline differences. [15][16][17] Second, in the overall population aged 70-79 years, we observed a 14% rate of combined RP and EBRT, which is higher than previously reported, despite significantly higher age distribution, relative to the two previous reports.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] Second, in the overall population aged 70-79 years, we observed a 14% rate of combined RP and EBRT, which is higher than previously reported, despite significantly higher age distribution, relative to the two previous reports. 13,14 After stratification according to age category 70-74 versus 75-79 the respectively rates of RP and EBRT were 13.5% and 21.7%. These rates were counterintuitive,…”

Section: Discussionmentioning

confidence: 99%

Non‐cancer mortality in elderly prostate cancer patients treated with combination of radical prostatectomy and external beam radiation therapy

et al. 2021

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Background: To test for rates of other cause mortality (OCM) and cancer-specific mortality (CSM) in elderly prostate cancer (PCa) patients treated with the combination of radical prostatectomy (RP) and external beam radiation therapy (EBRT) versus RP alone, since elderly PCa patients may be over-treated.Methods: Within the Surveillance, Epidemiology and End Results database (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016), cumulative incidence plots, after propensity score matching for cTstage, cN-stage, prostate specific antigen, age and biopsy Gleason score, and multivariable competing risks regression models (socioeconomic status, pathological Gleason score) addressed OCM and CSM in patients (70-79, 70-74, and 75-79 years) treated with RP and EBRT versus RP alone.Results: Of 18,126 eligible patients aged 70-79 years, 2520 (13.9%) underwent RP and EBRT versus 15,606 (86.1%) RP alone. After propensity score matching, 10-year OCM rates were respectively 27.9 versus 20.3% for RP and EBRT versus RP alone (p < .001), which resulted in a multivariable HR of 1.4 (p < .001). Moreover, 10-year CSM rates were respectively 13.4 versus 5.5% for RP and EBRT versus RP alone. In subgroup analyses separately addressing 70-74 year old and 75-79 years old PCa patients, 10-year OCM rates were 22.8 versus 16.2% and 39.5 versus 24.0% for respectively RP and EBRT versus RP alone patients (all p < .001). Conclusion:Elderly patients treated with RP and EBRT exhibited worrisome rates of OCM. These higher than expected OCM rates question the need for combination therapy (RP and EBRT) in elderly PCa patients and indicate the need for better patient selection, when combination therapy is contemplated.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Factores predictivos de toxicidad urinaria y rectal tras radioterapia externa conformada en el cáncer de próstata: correlación de parámetros clínicos, tumorales y dosimétricos con radioterapia radical y postoperatoria

Martínez-Arribas

Segundo

Cuesta-Álvaro

et al. 2017

Actas Urológicas Españolas

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Adjuvant Radiotherapy in Prostate Cancer Patients Treated with Surgery: The Impact of Age and Tumor Characteristics

Cited by 5 publications

References 24 publications

Pathological stage, surgical margin and lymphovascular invasion as prognostic factors after salvage radiotherapy for post-prostatectomy relapsed prostate cancer — outcomes and optimization strategies

Pathological stage, surgical margin and lymphovascular invasion as prognostic factors after salvage radiotherapy for post-prostatectomy relapsed prostate cancer — outcomes and optimization strategies

Non‐cancer mortality in elderly prostate cancer patients treated with combination of radical prostatectomy and external beam radiation therapy

Factores predictivos de toxicidad urinaria y rectal tras radioterapia externa conformada en el cáncer de próstata: correlación de parámetros clínicos, tumorales y dosimétricos con radioterapia radical y postoperatoria

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