Adjuvant radiotherapy on older and oldest elderly rectal cancer patients

Fiorica, Francesco; Cartei, F.; Carau, Barbara; Berretta, Salvatore; Spartà, D.; Tirelli, Umberto; Sant’Angelo, Antonino; Maugeri, D.; Luca, S. De; Leotta, C; Sorace, R; Berretta, Massimiliano

doi:10.1016/j.archger.2008.05.001

Cited by 28 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only two studies concomitantly assessed the feasibility rates of chemotherapy and radiotherapy [21,51]. Both were small sample studies (n 5 41 and n 5 36, respectively) in patients with rectal cancer and found very high radiotherapy feasibility rates, contrasting with a 77% rate of chemotherapy feasibility [21].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Solid Cancer Treatment Feasibility in Older Patients: A Prospective Cohort Study

Laurent

Paillaud

Tournigand³

et al. 2014

The Oncologist

View full text Add to dashboard Cite

Purpose. To assess solid cancer treatment feasibility in older patients Methods. Between 2007 and 2010, 385 consecutive elderly patients (mean age: 78.9 6 5.4 years; 47.8% males) with solid malignancies referred to two geriatric oncology clinics were included prospectively. We recorded feasibility of first-line chemotherapy (planned number of cycles in patients without metastases and three to six cycles depending on tumor site in patients with metastases), surgery (patient alive 30 days after successfully performed planned surgical procedure), radiotherapy (planned dose delivered), and hormonal therapy (planned drug dose given), and we recorded overall 1-year survival. Results. Main tumor sites were colorectal (28.6%), breast (23.1%), and prostate (10.9%), and 47% of patients had metastases. Planned cancer treatment was feasible in 65.7% of patients with metastases; this proportion was 59.0% for chemotherapy, 82.6% for surgery, 100% for radiotherapy, and 85.2% for hormonal therapy. In the group without metastases, feasibility proportions were 86.8% overall, 72.4% for chemotherapy, 95.7% for surgery, 96.4% for radiotherapy, and 97.9% for hormonal therapy. Factors independently associated with chemotherapy feasibility were good functional

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Solid Cancer Treatment Feasibility in Older Patients: A Prospective Cohort Study

Laurent

Paillaud

Tournigand³

et al. 2014

The Oncologist

View full text Add to dashboard Cite

show abstract

“…Fiorica et al . () also reported a much higher incidence of radiation dermatitis in their study, with all patients but one experiencing this side effect. Similar results were found in the study by Ishihara et al .…”

Section: Resultsmentioning

confidence: 70%

“…Diarrhoea was noted to be one of the most common acute side effects of preoperative radiotherapy (Fiorica et al . ). In a study to analyse the effects of adjuvant radiotherapy in elderly patients with rectal cancer this symptom occurred in 81·8% of patients, 61% of these reporting it to be transient (grade 1), 24·4% had a tolerable toxicity level (grade 2) and 2·4% experienced grade 3 diarrhoea (Fiorica et al .…”

Section: Resultsmentioning

confidence: 97%

“…At follow up, this had reduced to <10%, leading the authors to conclude that although radiotherapy has a significant impact on bladder function it occurs at a tolerable toxicity level (Fiorica et al . ).…”

Section: Resultsmentioning

confidence: 97%

“…In the study by Fiorica et al . (), acute grade 1 urinary problems occurred in over 50% of patients undergoing treatment. At follow up, this had reduced to <10%, leading the authors to conclude that although radiotherapy has a significant impact on bladder function it occurs at a tolerable toxicity level (Fiorica et al .…”

Section: Resultsmentioning

confidence: 98%

See 2 more Smart Citations