Adjuvant radiotherapy to a scalp wound reconstructed with Integra & split thickness skin graft: foolhardy or wise addition to treatment options of large skin defects?

A Two-Step Approach to the Surgical Treatment of Soft-Tissue Sarcomas

“…Unfortunately, inevitably, for some of our patients, this two-step approach resulted in a little delay in the initiation of radiation therapy because we never started radiation therapy protocols on patients to whom Integra had been applied for closing their wounds. In the literature, however, there are data on the possibility of applying small doses of radiation therapy on Integra while keeping the underlying tissue viable; this information, although currently limited to a few cases and applied in fields other than orthopedics, could be a valuable path to investigate in order to implement and improve our approach [48]. Moreover, a limitation of our study is also the fact that in some cases in the literature, following an R1 resection, adjuvant Some examples of two-stage procedures with the use of dermal substitutes with good results are found in the literature, mainly in the field of dermatology, but to our knowledge, no similar experience applied to soft-tissue sarcomas (STS) in the orthopedic field specifically is described in the literature [46,47].…”