Adjuvant Technologies in the Construction of Advanced Vaccines

Семакова, А. П.; Микшис, Н. И.

doi:10.21055/0370-1069-2016-2-28-35

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…In this regard, scientists study the polysaccharides of algae, whose influence on the formation of innate and adaptive immunity has been described in numerous papers in Russia and in other countries [75,87,88,104]. In the analysis of adjuvant technologies for the creation of vaccines, preference is given to modifiers of functions of the receptors of innate immunity and their signaling pathways [105]. The sulphate polysaccharides of brown algae have some excellent properties as adjuvants: almost complete absence of toxicity, safety, and excellent biocompatibility [106].…”

Section: Biopolymers Of Algae Are Adjuvants For the Influenza Vaccmentioning

confidence: 99%

Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection

Беседнова¹,

Ts²,

Кузнецова³

et al. 2019

Marine Drugs

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Context: Seaweed metabolites (fucoidans, carrageenans, ulvans, lectins, and polyphenols) are biologically active compounds that target proteins or genes of the influenza virus and host components that are necessary for replication and reproduction of the virus. Objective: This review gathers the information available in the literature regarding to the useful properties of seaweeds metabolites as potential agents for the prevention and therapy of influenza infection. Materials and methods: The sources of scientific literature were found in various electronic databases (i.e., PubMed, Web of Science, and ScienceDirect) and library search. The retrospective search depth is 25 years. Results: Influenza is a serious medical and social problem for humanity. Recently developed drugs are quite effective against currently circulating influenza virus strains, but their use can lead to the selection of resistant viral strains. In this regard, new therapeutic approaches and drugs with a broad spectrum of activity are needed. Metabolites of seaweeds fulfill these requirements. This review presents the results of in vitro and in vivo experimental and clinical studies about the effectiveness of these compounds in combating influenza infection and explains the necessity of their use as a potential basis for the creation of new drugs with a broad spectrum of activity.

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Section: Biopolymers Of Algae Are Adjuvants For the Influenza Vaccmentioning

confidence: 99%

Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection

Беседнова¹,

Ts²,

Кузнецова³

et al. 2019

Marine Drugs

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“…адъюванты на основе соединений полисахаридной природы На различных стадиях испытаний находится ряд современных адъювантов, способных не только усиливать поглощение антигена АПК или доставлять его в зоны локализации иммунокомпетентных клеток, но и выступать в качестве непосредственных иммуностимуляторов. При выборе адъюванта особое внимание уделяется эффективности формирования иммунологической памяти, способности к комплексной стимуляции Th1-и Th2-иммунного ответа, обеспечению выраженного иммунного ответа при снижении дозы вакцины и кратности вакцинации, отсутствию токсичности для организма [41].…”

Section: Iscomsunclassified

“…При анализе адъювантных технологий в создании современных вакцин на сегодняшний день предпочтение отдается модификаторам функций рецепторов врожденного иммунитета и их сигнальных путей [41]. Такими свойствами, наряду с высокой биосовместимостью, низ-Вопросы Вирусологии.…”

Section: сульфатированные пс (фукоиданы)unclassified

Adjuvants of Influenza Vaccines: New Possibilities of Using Sulphated Polysaccharides From Marine Brown Algae

Кузнецова

Persiyanova

et al. 2019

Problems of Virology

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The review article presents the characteristics of the main adjuvant groups (mineral salts of aluminum, synthetic squalene-based adjuvants - MF59 and AS03, CpG-oligodeoxynucleotides, virosomes, polyoxidonium, sovidone) included in the licensed influenza vaccine. The main mechanisms of adjuvant action, advantages and disadvantages of these adjuvants are shown. The vaccines adjuvants in the phase of experimental studies and clinical trials (ISCOMs, Advax™, chitosan) are described too. Particular attention is paid to sulfated polysaccharides (fucoidans) from marine brown algae as vaccine adjuvants. Numerous results of their application in compositions of experimental vaccines are presented. The prospects of sulfated polysaccharides using in the design of influenza vaccines are estimated. These prospects are determined by high biocompatibility, low toxicity and good tolerance of the human body to fucoidans, as well as mechanisms of their adjuvant activity. Sulfated polysaccharides are agonists of toll-like receptors of innate immunity cells and powerful inducers of the cellular and humoral immune response, which is important for the development of influenza vaccines. The review is based on the information presented in the bibliographic and abstract databases of scientific publications, search engines and publishers: RSCI, Web of Science, Scopus, MEDLINE, Google Scholar, PubMed, Springer Nature, Elsevier and others.

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Improving safety of oil adjuvant-based vaccines

Skupnevskii¹,

Pukhaeva²,

Badtiev³

et al. 2022

Russian Journal of Infection and Immunity

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High adjuvant reactogenicity is the main limitation for increasing the effectiveness of vaccine therapy. The aim was to reduce the immunotoxicity effects of complete Freunds adjuvant (CFA) in warm-blooded animals. Materials and methods. The study examined Wistar rats by dividing animals into negative control (solvents); positive control (single subcutaneous CFA injection of 0.1 ml/200 g body weight (b.w.)); the minimum and maximum (per os administration of 1:4 citric and succinic acids in ratio of 17 and 88 mg/kg b.w. during 4 weeks after immunization of CFA) experiment. Body weight, hematological (complete blood count) and biochemical (hydroperoxides, malondialdehyde, catalase activity, mitochondrial dehydrogenase activity) parameters were dynamically investigated. At the end of the experiment, necropsy was performed and the relative internal organ mass coefficients were calculated. The spleen and connective tissue (knee joint) were examined histologically. The median, C25C75 quartiles, MannWhitney U-test were calculated. Results and discussion. it was found that parameters examined were within normal range in animals of negative control group. Immunization of warm-blooded animals with CFA was accompanied by transition of acute-to- chronic inflammatory reaction (week 3 and week 7, respectively). The total leukocyte count increased from 12.5 109 (negative control) up to 26.6 109/L (P = 0.01) on week 3 followed by its decline down to 19.2 109/L (P = 0.01) by week 7. Platelet count also increased significantly: from 506 109 (negative control) up to 656 109/L (P = 0.01, week 3) followed by decrease down to 610 109/L by week 7 (P = 0.01). Activation of lipid peroxidation was manifested by malondialdehyde (MDA) level elevated by 55.861.8% (P = 0.01); the general CFA-related toxic effect resulted in 11.7% weight loss (P = 0.01), spleen swelling and thymus reduction. Administration of antioxidant acids led to a dose-dependent decline in inflammation (leukocyte count at the minimum dosage 19.6 10920.9 109/L; at the maximum 16.6 10916.0 109/L), as well as normalized the platelet/leukocyte index up to 29.536.3 (positive control 24.6, negative control 40.5). The acid-related protective effect was also manifested as maintained body weight, activated catalase and inhibited lipid peroxidation. The therapeutic effect in alleviated degenerative changes in the spleen and connective tissue were revealed: reduced hemorrhagic focuses and swelling as well as preserved histoarchitectonics. Conclusion. The use of citric and succinic acids contributes to profoundly lowered CFA toxicity due to increased total antioxidant status, inhibited lipid peroxidation, improved mitochondrial metabolic activity, which ultimately lead to a decline in general systemic inflammation and allows to recommend such acids as immunoprotectors from oil adjuvant-coupled effects.

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Adjuvant Technologies in the Construction of Advanced Vaccines

Cited by 7 publications

References 17 publications

Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection

Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection

Adjuvants of Influenza Vaccines: New Possibilities of Using Sulphated Polysaccharides From Marine Brown Algae

Improving safety of oil adjuvant-based vaccines

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