Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Almeida, Juliano Milanezi de; Ervolino, Edílson; Novaes, Vivian Cristina Noronha; Theodoro, Letícia Helena; Fernandes, Leandro Araújo; Martins, Tiago Marchi; Faleiros, Paula Lazilha; Garcia, Valdir Gouveia

doi:10.1902/jop.2015.150166

Cited by 44 publications

(63 citation statements)

References 51 publications

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“…The mechanical removal of dental plaque by SRP is the base of periodontal treatment, but may be flawed in some dental sites 2 . Thus, the aim of this study was to evaluate the local effects of statins as an adjuvant treatment to SRP in periodontal disease induced in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Periodontal disease (PD) is a chronic infection produced by Gram-negative bacteria with high prevalence levels 2 . It occurs in gingiva in response to bacterial antigens of dental plaque, which accumulate along the gingival margin.…”

Section: Introductionmentioning

confidence: 99%

“…However, mechanical therapy alone may be unsuccessful to eliminate pathogenic bacteria for they are usually located within either soft or hard tissues, or even in areas that are inaccessible to periodontal instruments, such as areas of furcation and root depressions 2 . Due to these limitations, supporting methods for conventional periodontal therapy have been studied 7 , 27 .…”

Section: Introductionmentioning

confidence: 99%

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Local application of statins in the treatment of experimental periodontal disease in rats

et al. 2017

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Objective The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats.Material and Methods Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis.Results The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods.Conclusions Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Local application of statins in the treatment of experimental periodontal disease in rats

et al. 2017

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“…In hard tissue healing, it primarily inhibits the receptor activator of nuclear factor kappa B (RANK) signaling pathway and macrophage colony-stimulating factor (M-CSF) expression, leading to reduced osteoclast formation and bone resorptive capacity [30]. In soft tissue healing, it acts as a wound-healing enhancer with anti-inflammatory and antimicrobial biological properties.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of alendronate as an adjunct to scaling and root planing in the treatment of periodontitis: a meta-analysis of randomized controlled clinical trials

Chen

et al. 2016

J Periodontal Implant Sci

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PurposeAlendronate has been proposed as a local and systemic drug treatment used as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. However, its effectiveness has yet to be conclusively established. The purpose of the present meta-analysis was to assess the effectiveness of SRP with alendronate on periodontitis compared to SRP alone.MethodsFive electronic databases were used by 2 independent reviewers to identify relevant articles from the earliest records up to September 2016. Randomized controlled trials (RCTs) comparing SRP with alendronate to SRP with placebo in the treatment of periodontitis were included. The outcome measures were changes in bone defect fill, probing depth (PD), and clinical attachment level (CAL) from baseline to 6 months. A fixed-effect or random-effect model was used to pool the extracted data, as appropriate. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using the Cochrane χ2 and I2 tests.ResultsAfter the selection process, 8 articles were included in the meta-analysis. Compared with SRP alone, the adjunctive mean benefits of locally delivered alendronate were 38.25% for bone defect fill increase (95% CI=33.05–43.45; P<0.001; I2=94.0%), 2.29 mm for PD reduction (95% CI=2.07–2.52 mm; P<0.001; I2=0.0%) and 1.92 mm for CAL gain (95% CI=1.55–2.30 mm; P<0.001; I2=66.0%). In addition, systemically administered alendronate with SRP significantly reduced PD by 0.36 mm (95% CI=0.18–0.55 mm; P<0.001; I2=0.0%) and increased CAL by 0.39 mm (95% CI=0.11–0.68 mm; P=0.006; I2=6.0%).ConclusionsThe collective evidence regarding the adjunctive use of alendronate locally and systemically with SRP indicates that the combined treatment can improve the efficacy of non-surgical periodontal therapy on increasing CAL and bone defect fill and reducing PD. However, precautions must be exercised in interpreting these results, and multicenter studies evaluating this specific application should be carried out.

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“…25,36 Previous studies have demonstrated the effects of systemic alendronate in human 37,38 and animal models 39,40 in decreasing loss and increasing density of alveolar bone. de Almeida et al 41 concluded that topical use of sodium alendronate as an adjuvant to scaling and root planing (SRP) shown to be effective in treatment of experimental periodontitis. Goes et al 42 found that alendronate prevented reduction of bone-specific alkaline phosphatase serum levels (BALP), alveolar bone loss and reduced inflammatory infiltrate, without causing systemic alterations.…”

Section: Use Of Bisphosphonates In Diagnosis and Management Of Periodmentioning

confidence: 99%

The Effect of Bisphosphonates and Low-Dose Doxcycline Therapy in Diabetics With Periodontitis: A Review

Doğan¹,

Dede²

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Abstract: It can be concluded that topical use of SA as an adjuvant to SRP is effective in the treatment of experimental periodontitis.

Cited by 44 publications

References 51 publications

Local application of statins in the treatment of experimental periodontal disease in rats

Local application of statins in the treatment of experimental periodontal disease in rats

Effectiveness of alendronate as an adjunct to scaling and root planing in the treatment of periodontitis: a meta-analysis of randomized controlled clinical trials

The Effect of Bisphosphonates and Low-Dose Doxcycline Therapy in Diabetics With Periodontitis: A Review

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