Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

Abstract

Early PCV, either before or after RT, appears to improve OS of participants with AO or AOA. Use of biomarkers including codeletion of chromosomes 1p and 19q with or without IDH-1 or -2 mutation identify a subset of people with increased sensitivity to combined PCV and RT. The important role of biomarkers was supported in all of the RCTs examined, and prospective evaluation should be undertaken in future studies. However, PCV was associated with significant grade 3 and 4 toxicities, and whether temozolomide can be substituted for this remains unclear.

Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III

“…Diffusely infiltrating gliomas have now been grouped together not only based upon the behavioral hierarchy and growth patterns but also on the basis of genetic mutations in the IDH1(isocitrate dehydrogenase) and IDH2 genes 2 . The key genotypic feature of an oligodendroglioma, the presence of 1p/19q codeletion, differentiates it from diffuse astrocytoma and is associated with improved radio-and chemotherapeutic sensitivity and survival [3][4][5] .…”

Adult Diffuse Low-Grade Gliomas: 35-Year Experience at the Nancy France Neurooncology Unit

“…In our series, the association PCV + RT is associated with long survivals with a median OS close to 20 years. Nevertheless, several studies show that the association PCV+RT has a significant toxicity (47,48). Moreover, we do not have precise data concerning the long-term outcome of patients treated with PCV+RT in regards on cognition and QoL (49,50).…”

Differentiation of grade II and III oligodendrogliomas from grade II and III astrocytomas: a histogram analysis of perfusion parameters derived from dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI

“…However, this can be difficult if the tumor involves the eloquent area (7)(8)(9). In that case, since oligodendrogliomas are chemo-responsive (procarbazine, lomustine, and vincristine) tumors, treatment could be partial resection, followed by adjuvant chemotherapy and radiation therapy (10,11). Accordingly, the preoperative distinction of OT from AT would facilitate the planning of the extent of resection.…”