Adjuvant whole brain radiation following resection of brain metastases

Slottje, David F.; Kim, Joon Hyung; Wang, Lisa; Raper, Daniel; Shah, Ashish H.; Bregy, Amadé; Furlong, Melissa; Madhavan, Karthik; Lally, Brian E.; Komotar, Ricardo J.

doi:10.1016/j.jocn.2012.09.026

Cited by 2 publications

(2 citation statements)

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“…Postoperative treatment includes WBRT, chemotherapy, and a combination of WBRT and chemotherapy. Adjuvant WBRT improves local tumor control and survival . Our results showed that WBRT prolonged survival by 3.5 months (12.1 vs. 8.6 months).…”

Section: Discussionmentioning

confidence: 52%

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Prognostic factors and outcome of surgically treated patients with brain metastases of non‐small cell lung cancer

Chen

Wang

et al. 2018

Thoracic Cancer

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BackgroundBrain metastases (BM) are a common consequence of lung cancer and surgery is effective; however, the factors affecting survival after surgery are unclear. The aim of this study was to identify the outcomes and prognoses of post‐metastasectomy patients with BM from non‐small cell lung cancer (NSCLC) at a single institution over a 15‐year period.MethodsNSCLC patients who had undergone BM surgery were retrospectively identified. Survival was analyzed using the Kaplan–Meier curve, and univariate and multivariate factors associated with survival were identified using the Cox proportional hazards model.ResultsThe median overall survival was 9.8 months, 18 (14.8%) patients survived > 24 months, and 6 (4.9%) > 36 months. The one and two‐year survival rates were 41% and 18.6%, respectively. Univariate analysis revealed that recursive partitioning analysis (RPA) classification, Karnofsky Performance Scale (KPS) scores, BM number, extracranial metastasis status, different lesion locations, resection extent, postoperative treatment, and salvage therapy after recurrence significantly influenced patient survival. The different treatment modalities for primary lesions also affected postoperative survival. KPS ≥ 70, RPA class I/II, and postoperative chemotherapy were independent factors that decreased the risk of death from BM. Interestingly, the initial onset of intracranial lesions could increase the risk of death from BM.ConclusionA KPS score ≥ 70, RPA class I/II, and postoperative chemotherapy could benefit post‐metastasectomy patients with BM from NSCLC. Conversely, the initial onset of intracranial lesions is an unfavorable factor that increases the risk of death. These findings support the use of personalized therapy for patients with BM from NSCLC.

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Section: Discussionmentioning

confidence: 52%

“…Adjuvant WBRT improves local tumor control and survival. 13,[24][25][26] Our results showed that WBRT prolonged survival by 3.5 months (12.1 vs. 8.6 months). Interestingly, chemotherapy increased the mean survival duration from 8.6 to 12.3 months, while chemotherapy combined with WBRT could prolong survival to 14.5 months.…”

Section: Discussionmentioning

confidence: 52%