Administering an Appeasing Substance to Improve Performance, Neuroendocrine Stress Response, and Health of Ruminants

Cappellozza, Bruno I; Cooke, Reinaldo F

doi:10.3390/ani12182432

Cited by 8 publications

(9 citation statements)

References 105 publications

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“…Plasma concentration of cortisol upon slaughter was decreased ( P < 0.01) by 44% in mBAS steers compared to CON+ ( Table 3 ). This outcome supports our hypothesis and provides initial evidence that mBAS administration alleviated the stress elicited during processing for slaughter ( Cappellozza and Cooke, 2022 ). Cortisol is paramount to the adrenocortical stress response ( Sapolsky et al., 2000 ) and directly stimulates glycogen and muscle tissue breakdown ( Nelson and Cox, 2005 ).…”

Section: Resultssupporting

confidence: 89%

“…2020 ; Schubach et al., 2020 ), BW gain was not expected to differ herein given the short length of mBAS administration and the lack of major stressors during the final 7 days on feed. The mBAS replicates the composition of the original bovine appeasing pheromone that has calming effects when perceived by the animal, and shown to improve welfare and productivity of cattle exposed to stressful procedures ( Cappellozza and Cooke, 2022 ). No treatment differences were observed ( P = 0.73) for proportion of carcasses that graded Choice or Prime ( Table 2 ), as mBAS was also not expected to affect marbling during the last week on feed.…”

Section: Resultsmentioning

confidence: 99%

“…The maternal bovine appeasing substance ( mBAS ) is a mixture of fatty acids that replicate the composition of the original bovine appeasing pheromone, and shown to alleviate the physiological consequences elicited by stressful management procedures ( Cappellozza and Cooke, 2022 ). Research from our group reported that mBAS administration reduced cortisol concentrations and inflammatory reactions in beef calves upon weaning ( Schubach et al., 2020 ) and in feedlot steers during the receiving period ( Colombo et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Administering the maternal appeasing substance before slaughter to improve carcass characteristics of finishing cattle

Mackey,

Cooke,

Pickett

2024

Translational Animal Science

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Two experiments evaluated carcass characteristics of finishing steers administered the maternal bovine appeasing substance (mBAS) prior to slaughter. In Exp. 1, 954 Angus-influenced finishing steers housed in 6 original pens were used. Each original pen was split into a pair of experimental pens 14.3 d ± 3 d prior to slaughter, in a manner that number of steers and average pen body weight (BW; 636 ± 4 kg) were similar. An oiler containing mBAS (Ferappease® Finish Cattle 5%; FERA Diagnostics and Biologicals; College Station, TX) was added to one of the experimental pens 7 d prior to slaughter (n = 6), whereas the other pen did not contain an oiler (CON; n = 6). The oiler delivered 120 ml of mBAS/steer during a 7-d period. Steer BW was recorded 7 d prior to and during loading (final BW) to the packing plant. No treatment effects were detected (P ≥ 0.51) for BW gain, final BW, and proportion of carcasses that graded Choice or Prime. Carcass dressing percentage was greater (P = 0.02) in mBAS compared with CON steers (65.9 vs. 64.2%; SEM = 0.5), which was not sufficient to impact hot carcass weight (HCW; P = 0.29). Incidence of dark-cutting carcasses did not differ between treatments (P = 0.23). In Exp. 2, 80 Angus-influenced finishing steers housed in 16 pens (5 steers/pen; 600 ± 4 kg of BW) were used. Pens were arranged in 4 rows of 4 pens/row, and rows were alternately assigned to receive an oiler containing mBAS (n = 8) or mineral oil (CON+; n = 8) 7 d prior to slaughter. Oilers were designed to deliver 120 ml/steer of mBAS or mineral oil during the 7-d period. Steer BW was recorded as in Exp. 1, and a blood sample was collected during exsanguination. No treatment effects were detected (P ≥ 0.20) for BW parameters, carcass marbling score, backfat thickness, Longissimus muscle area, yield grade, and proportion of carcasses that graded Choice or Prime. Carcass dressing was greater (P = 0.02) in mBAS steers compared with CON+ (60.6 vs. 59.6%; SEM = 0.3) but HCW did not differ (P = 0.47) between treatments. Plasma cortisol concentration was less (P < 0.01) in mBAS steers compared with CON+ (11.7 vs. 20.8 ng/mL; SEM = 1.6). Incidence of dark-cutting carcasses did not differ (P = 0.53) between treatments. In summary, mBAS administration to finishing cattle using oilers during the last 7 d on feed alleviated the adrenocortical stress response elicited by the process of slaughter, which likely resulted in increased carcass dressing.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Administering the maternal appeasing substance before slaughter to improve carcass characteristics of finishing cattle

Mackey,

Cooke,

Pickett

2024

Translational Animal Science

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“…The mechanism through which BAS administration leads to reduced cortisol production is still unclear. However, it is known that BAS target organs involved in pheromone perception include the main olfactory epithelium (MOE) and vomeronasal organ (VNO; [28,29]). The MOE is responsible for the recognition of traditional odor molecules and chemical and environmental signals without specificity or meaning, whereas the VNO is related to pheromone recognition, carrying specific chemosensory signals through the receptors [30], leading to the occurrence of a neuroendocrine cascade [29].…”

Section: Discussionmentioning

confidence: 99%

Effects of an Appeasing Substance Application at Weaning on Growth, Stress, Behavior, and Response to Vaccination of Bos indicus Calves

Vieira,

Vedovatto,

Fernandes

et al. 2023

Animals

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An analog of a bovine-appeasing substance (BAS) was previously demonstrated to have calming effects, and it could be an alternative to alleviate the stress caused by weaning. Thus, the objective of this study was to evaluate the effects of BAS administration at weaning on growth, stress, behavior, and response to vaccination of Nellore calves. Eighty-six Nellore calves (40 females and 46 males) were abruptly weaned and randomly assigned into 1 of 2 treatments: (1) saline solution (0.9% NaCl; n = 43) and (2) BAS (Secure Catte, IRSEA Group, Quartier Salignan, France; n = 43). The solutions were topically applied (5 mL/calf) to the nuchal skin area of each animal. On d 0, before treatment application, calves were vaccinated against infectious bovine rhinotracheitis (IBR), parainfluenza-3 (PI3) virus, and bovine viral diarrhea virus types 1 and 2 (BVDV-1 and 2). Calves from each treatment were kept in different pastures for 15 d (time of BAS action) and then moved to a single pasture. Body weight (BW), blood samples, and temperament in the chute (entry score, chute score, and exit score) were collected on d 0, 3, 8, 15, 51, and 100, and behavior on pasture on d 1, 2, 4, 5, 6, 7, and 9. Calves assigned to BAS vs. Saline treatment tended to have greater BW on d 15 (p = 0.10), tended to have lower entry scores on d 8 and 51 (p = 0.10), and chute scores on d 8 (p = 0.07), and had lower exit scores on d 8 (p = 0.02). Calves assigned to BAS vs. Saline treatment also had greater time grazing on d 7 and 9 (p < 0.01), eating concentrate on d 2, 5, and 6 (p = 0.05), walking on d 1, 2, 5, and 9 (p < 0.01), standing and ruminating on d 2, 7 and 9 (p < 0.01), and playing on d 2, 4, 6, 7, and 9 (p < 0.01). Furthermore, they had lower time lying on 1 and 2 (p < 0.01), standing on d 5 and 9 (p < 0.01), and vocalizing on d 1 and 2 (p < 0.01). Calves assigned to BAS vs. Saline treatment had greater serum titter concentrations of PI3 t on d 15 and 51 (p = 0.05) and BVDV-1 on d 51 (p = 0.02). However, they had lower serum concentrations of cortisol on d 3 (p = 0.03). BAS administration did not affect (p ≥ 0.12) the serum titer concentration of IBR and BVDV-2 titers or the plasma concentration of haptoglobin and ceruloplasmin. The BAS administration improved BW, reduced temperament and serum cortisol concentration, and improved behavior and response to vaccination.

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“…However, industrial environmental conditions for animals lead to technological stresses leading to performance and health losses that cause higher susceptibility to pathogens iincrease's their exposure to viral and bacterial agents that causes mastitis, salmonellosis. Stressors have been proven to alter the permeability of intestinal barriers, gene and protein profiles of pro-inflammatory cytokines and chemokines in mucosal membranes in animals that increase plasma concentrations of proinflammatory cytokines and acute-phase proteins [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of hematological and oxidative parameters characterizing the nonspecific resistance of cows under technological stress

Deryugina,

Ivashchenko,

Danilova

et al. 2024

BIO Web Conf.

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The aim of the work was to study the dynamics of biochemical, hormonal and oxidative parameters in the blood of cattle from the point of view of nonspecific resistance of animals under the action of technological stress. Technological stress was accompanied by the entry of cortisol into the blood, a significant intensification of lipid peroxidation processes, a decrease in the activity of the antioxidant system of the blood, and a change in the nonspecific resistance of the animal organism. On day 1 after technological stress, the content of cortisol and the level of DC in the blood increased by 2 times, an increase in MDA and OR, a decrease in catalase and reduced glutathione were observed. The most pronounced changes were recorded on days 3-14 after technological stress. The animals showed neutrophilia, monocytosis, lymphopenia and appearance of NEToses on days 3 and 14 after technological stress. On the 3rd day after technological stress, an increase in lysozyme activity of blood serum and a decrease in bactericidal activity were shown. Preservation of reduced indicators of reduced glutathione and lysozyme activity while maintaining cortisol at the upper limit of indicators relative to the initial values was recorded by 30 days in cows after technological stress. The data obtained indicate that the body’s defenses are a dynamic physiological indicator, which must be taken into account as a general resistance of the cattle body to stressors in order to prevent the disruption of the body’s adaptive capabilities.

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Administering an Appeasing Substance to Improve Performance, Neuroendocrine Stress Response, and Health of Ruminants

Cited by 8 publications

References 105 publications

Administering the maternal appeasing substance before slaughter to improve carcass characteristics of finishing cattle

Administering the maternal appeasing substance before slaughter to improve carcass characteristics of finishing cattle

Effects of an Appeasing Substance Application at Weaning on Growth, Stress, Behavior, and Response to Vaccination of Bos indicus Calves

Dynamics of hematological and oxidative parameters characterizing the nonspecific resistance of cows under technological stress

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