Administración de fármacos por sonda digestiva

Viguria, R. Goñi; Sanz, L. Sánchez; Indave, A. Baztán; Erro, M.C. Asiaín

doi:10.1016/s1130-2399(01)78019-4

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…An alternative that may be considered for the dissolution/dispersion of tablets is to use an oral syringe, because it provides a closed system which avoids the direct contact of the drug with the professional and the spread of drug particles into the air . In this context, the literature cites several compatible vehicles such as water, dextrose 5% and simple syrup …”

Section: Resultsmentioning

confidence: 99%

“…For this purpose, using the compounded formulation prepared with the powder of the tablets dispersed in a compatible vehicle (simple syrup, Ora‐Plus ® or Ora‐Sweet ® ) is recommended. However, if no environment with a controlled vents system is available, it is recommended that the tablets be dispersed in water within an oral syringe and then administered immediately through the enteral tube.…”

Section: Resultsmentioning

confidence: 99%

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Immunosuppressives and enteral feeding tubes: An integrative review

et al. 2019

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What is known and objective: Immunosuppression is the main goal in the treatment of autoimmune diseases, chronic inflammatory diseases, and solid organ and tissue transplantation. However, due to a lack of liquid-form medications, it is challenging to achieve adequate immunosuppression when the patient is using enteral feeding tubes. It is necessary to transform solid oral medications into other forms for administration. Besides that, the occupational risk should be considered, and safetyhandling measures should be taken. This review aimed to investigate the available evidence regarding the use of immunosuppressive drugs through enteral feeding tubes, focusing on the administration technique, efficacy and treatment safety. Methods:We performed an integrative review using the databases PubMed, LILACS, SciELO, Cochrane and Google Scholar, including papers published between 1997 and 2017 in Portuguese, English and Spanish. We excluded editorials, theoretical reflections, abstracts presented at events, dissertations, theses, monographs and studies with extemporaneous formulations administered only by the oral route. In addition, we investigated the references of the included papers, as well as pharmaceutical guides, books and package inserts of selected drugs for additional evidence.Information and recommendations found were analysed and classified according to the GRADE system. Results and discussion:Fifty papers were identified, and 14 met the selection criteria. Among the assessed immunosuppressive drugs, we observed that tacrolimus, mycophenolic acid derivatives and azathioprine were the most studied, and they have more guided recommendations regarding their use through enteral feeding tubes.We noted the need for personal protective equipment for the conversion of the solid oral dosage forms, along with special caution during administration, due to occupational hazard. Other important factors identified were the position of the tube and interactions with the enteral nutrition, because they may compromise absorption, bioavailability and serum blood levels of immunosuppressive agents. However, the studies found have methodological limitations and poor quality, and this was taken into consideration during the classification of the evidence. | 409 e SILVA et AL.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Immunosuppressives and enteral feeding tubes: An integrative review

et al. 2019

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“…2,6,8,9,14 We also assessed the forms of presentation (pills, capsules, coated tablets of enteric or extended release drugs) and the possibility of being pulverized. We focused mainly on the forms of presentation including acronyms related to enteric-coated drugs or extended-release drugs, since when these types of drugs are pulverized they undergo a pharmacokinetic intervention performed by the site in the digestive apparatus where the feeding tube is placed, changing its bioavailability and posing the risk of drug poisoning2,8,9 (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…These data constituted the protocol shown in Table 2. 2,6,8,9,14 In order to test if there were statistically significant differences, the Fisher's exact test was used regarding proportions and the Student's T test was used regarding means. Values lower than 5% were considered to be statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Medicamentos e sondas de nutrição

Gorzoni

Torre

Pires

2010

Rev. Assoc. Med. Bras.

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Objective. To define the prevalence of use of drugs incompatible with the enteral route in patients living in long stay institutions for the elderly LTCFs and using feeding tubes. MethOds. Analysis of prescriptions for LTCF inpatients who are using feeding tubes for longer than 48 hours. Active ingredients, forms of presentation, and possibility of pulverizing the drugs prescribed were compared with data in the literature regarding the feasibility of the enteral administration of drugs. Results. We found that 57 patients were using feeding tubes (11.2% of the total number of beds). Their mean age was 65.6 ± 16.0 years old, and 32 of them were women and 25 were men. Mean of drugs administered through enteral route: 5.6 ± 2.2. Items included in the prescriptions: 316 divided into 64 drugs, with 129 items (40.8% of the total) and 23 drugs (35.4%) inadequate for this route. The most often prescribed inappropriate drugs: captopril, phenytoin, ranitidine, omeprazole, and B complex. Alternative presentations were found for 15 (65.2%) of the 23 drugs that were not appropriate for enteral administration. cOnclusiOn. Feeding tubes used as a method to administer drugs in LTCF have a significant risk for incompatible prescriptions.

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“…Crushing solids before administering them may present various problems, especially when crushing changes the medication's pharmacokinetics and pharmacological action (4) . It is worth highlighting that some dosage forms are unsuitable for tubes or enterostomy administration.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Intensivist-Nurses’ Knowledge Concerning Medication Administration Through Nasogastric and Enteral Tubes

Mota

Barbosa

Studart

et al. 2010

Rev. Latino-Am. Enfermagem

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This study evaluates the knowledge of nurses working in intensive care units concerning recommendations for the proper administration of medication through nasogastric and enteral tubes. This exploratory-descriptive study with a quantitative approach was carried out with 49 nurses in an intensive care unit of a tertiary hospital in Fortaleza, CE, Brazil.A total of 36.7% of nurses reported they disregard the dosage forms provided by the pharmacy at the time of administering the medication through tubes. Metal, wood, or a plastic mortar is the method most frequently reported (42.86%) for crushing prescribed solid forms; 32.65% leave the drugs in 20ml of water until dissolved; 65.3% place the responsibility for choosing the pharmaceutical formulation and its correlation with the tube site, either into the stomach or into the intestine, on the physician. The results indicate there is a gap between specific literature on medication administered through tubes and knowledge of nurses on the subject. Evaluación del conocimiento del enfermero de terapia intensiva sobre administración de medicamentos por sonda nasogástrica y nasoentéricaEl objetivo del estudio fue evaluar los conocimientos del enfermero de la unidad de cuidados intensivos sobre las recomendaciones para la correcta administración de medicamentos por sonda nasogástrica y nasoentérica. Se trata de un estudio exploratorio-descriptivo y cuantitativo con 49 enfermeros en una unidad de cuidados intensivos de un hospital terciario, en la ciudad de Fortaleza, estado de Ceará, Brasil. 36,7% no prestan atención a las formas disponibles en el sector de farmacia en el momento de su utilización por sonda. El pilón de metal, madera o plástico fue el método más citado (42,86%) para triturar las formas sólidas prescritas. 32,65% dejan los fármacos en 20mL de agua hasta que se disuelvan. 65,3% atribuyen al médico la responsabilidad de decidir sobre la formulación y la correlación con la ubicación de la sonda en el tracto gastrointestinal.Los resultados indican que hay una diferencia entre la literatura para los medicamentos administrados por sonda y el conocimiento de los enfermeros sobre el tema.

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Administración de fármacos por sonda digestiva

Cited by 4 publications

References 10 publications

Immunosuppressives and enteral feeding tubes: An integrative review

Immunosuppressives and enteral feeding tubes: An integrative review

Medicamentos e sondas de nutrição

Evaluation of Intensivist-Nurses’ Knowledge Concerning Medication Administration Through Nasogastric and Enteral Tubes

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