Administration d’aérosols médicamenteux au cours de la ventilation mécanique

Ehrmann, S.; Guillon, Antoine; Mercier, Emmanuelle; Vecellio, Laurent; Dequin, Pierre François

doi:10.1007/s13546-011-0338-8

Cited by 7 publications

(7 citation statements)

References 53 publications

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“…A large amount of nebulized dose was found both in inspiratory and expiratory line. As recommended by the manufacturer and also confirmed by independent studies 26 , nebulizer was placed as far as possible from the Y piece. The rational is to decrease deposition lost over expiratory line during inspiration.…”

Section: Discussionmentioning

confidence: 89%

“…Indeed, water contained in the aerosolized particles equilibrates with the surrounding humidity, thus increasing the volume of particles in a water-saturated environment. This has the effect of increasing the particle impaction at the level of the upper airways and thereby decreasing aerosol delivery into the lungs 26,30 . Consequently, despite the possibility allowed by manufacturer, no heated humidifier was used and no gas humidification was performed during this study.…”

Section: Discussionmentioning

confidence: 99%

“…As a recent review about aerosoltherapy under MV 26 recommend it, inspiratory flow was set as low as possible for chosen I/E ratio and respiratory rate leading to 35 L/min.…”

Section: Methodsmentioning

confidence: 99%

“…5) making use of this later one as an aerosol tank as explained by Erhmann et al . 26 when performing continuous nebulization.

Figure 5Experimental setup during 99m Tc-DTPA nebulization and place of nebulizer on the inspiratory valve…”

Section: Methodsmentioning

confidence: 99%

“…Since the aerosol particles generated may damage the flow sensor, it is recommended to place a filter before the expiratory valve 26 . This condition was respected for this study.…”

Section: Methodsmentioning

confidence: 99%

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Aerosol delivery during invasive mechanical ventilation: development of a preclinical ex vivo respiratory model for aerosol regional deposition

Montigaud

Georges

Pourchez

et al. 2019

Sci Rep

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In intensive care units, nebulization is a usual route for drug administration to patients under mechanical ventilation (MV). The effectiveness of inhalation devices as well as depositions sites of aerosols for ventilated patients remain poorly documented. In vivo human inhalation studies are scarce due to ethical restrictions because imaging techniques require radioaerosols to assess regional aerosol deposition. Thus, we developed an ex vivo respiratory model under invasive MV for preclinical aerosol deposition studies. The model was composed of ex vivo porcine respiratory tracts. MV was achieved thanks to a tracheal intubation and a medical ventilator under controlled conditions. Respiratory features were studied using analogical sensors. Then regional homogeneity of gas-ventilation was assessed with 81mKrypton scintigraphies. Finally, a proof of concept study for aerosol deposition was performed. Obtained respiratory features as well as gamma-imaging techniques, which demonstrated a homogenous regional ventilation and about 18% ± 4% of the nebulized dose deposited the respiratory tract, were in good agreement with human data available in the literature. This original ex vivo respiratory model provides a feasible, reproducible and cost-effective preclinical tool to achieve aerosol deposition studies under MV.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…As a recent review about aerosoltherapy under MV 26 recommend it, inspiratory flow was set as low as possible for chosen I/E ratio and respiratory rate leading to 35 L/min.…”

Section: Methodsmentioning

confidence: 99%

“…5) making use of this later one as an aerosol tank as explained by Erhmann et al . 26 when performing continuous nebulization.

Figure 5Experimental setup during 99m Tc-DTPA nebulization and place of nebulizer on the inspiratory valve…”

Section: Methodsmentioning

confidence: 99%

“…Since the aerosol particles generated may damage the flow sensor, it is recommended to place a filter before the expiratory valve 26 . This condition was respected for this study.…”

Section: Methodsmentioning

confidence: 99%

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