Administration de molécules actives dans les cellules

Poillot, Cathy; Waard, Michel De

doi:10.1051/medsci/2011275019

Med Sci (Paris)

2011

DOI: 10.1051/medsci/2011275019

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Administration de molécules actives dans les cellules

Cathy Poillot

Michel De Waard

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Cited by 8 publications

References 56 publications

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A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells

Lin

Zheng

et al. 2013

Targ Oncol

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Therapeutic peptides have been proven useful for treating various diseases. However, it is difficult for therapeutic peptides to reach their target sites with an effective concentration due to inefficient intracellular delivery. Although Tat transduction peptide is a promising tool to deliver therapeutic peptides into cells, the entrapment within endosomes and the nuclear localization of Tat transduction peptide severely limited the biological effects of Tat-linked cargos. In this study, we designed a novel peptide delivering system, Tat-INF7-ubiquitin (TIU), which consisted of Tat transduction peptide, endosomal escape enhancer peptide INF7, and ubiquitin protein. We found that the TIU system was able to efficiently deliver the mCherry fluorescent proteins and the apoptosis-inducing Bak BH3 peptide into the cytosol. The Bak BH3 peptide transported into the cells by the TIU system increased the apoptotic rate to 46.15 ± 4.86% (p < 0.001) in A549 cells, while Tat-BH3 could result in only 20.45 ± 2.89%. These results demonstrated that the TIU system could enhance the effects of therapeutic peptides by facilitating the transmembrane delivery of peptides into the cells and the escape of target proteins from the endosome efficiently.

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A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells

Lin

Zheng

et al. 2013

Targ Oncol

View full text Add to dashboard Cite

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Early stages of interactions of cell-penetrating peptide penetratin with a DPPC bilayer

Pourmousa

Karttunen

2013

Chemistry and Physics of Lipids

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Lipid nanocapsule functionalization by lipopeptides derived from human papillomavirus type-16 capsid for nucleic acid delivery into cancer cells

Weyland

Griveau

Bejaud

et al. 2013

International Journal of Pharmaceutics

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Administration de molécules actives dans les cellules

Cited by 8 publications

References 56 publications

A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells

A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells

Early stages of interactions of cell-penetrating peptide penetratin with a DPPC bilayer

Lipid nanocapsule functionalization by lipopeptides derived from human papillomavirus type-16 capsid for nucleic acid delivery into cancer cells

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