Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions

Abstract

BackgroundAdhesions formation is a significant postsurgical complication. At present, there is no effective method for preventing adhesions formation [1], although barrier products such as Dextran (Dex) [2] and sodium hyaluronate (SH) [3] have proved the most clinically successful [4-6], This study is designed to investigate the preventive and therapeutic potential of a novel penicillamine-bound membrane for abdominal adhesions formation.Methods150 rats were involved in the present study. All animals were randomly divided into 6 groups (1 vehicle group and 5 test groups respectively treated with dextran, sodium hyaluronate, penicillamine, penicillamine-bound membrane or non-penicillamine-bound membrane). The occurrence, grade and score of abdominal adhesions were compared between the different groups. The breaking strength of incision was compared between the vehicle group and the penicillamine, membrane with/without penicillamine - treated groups. Expression of collagen type I was compared between the vehicle and penicillamine-treated group. The occurrence of adhesions was compared between the Dextran (Dex), sodium hyaluronate (SH), penicillamine-treated group and membrane with or without penicillamine- treated groups.ResultsPenicillamine and penicillamine-bound membrane had significant preventive effects on abdominal adhesions formation, better than dextran, sodium hyaluronate and non-penicillamine-bound membrane. However, neither of them influenced incision healing, although they insignificantly decreased the breaking strength of the incision. Penicillamine-bound membrane, which can be loaded locally and more efficaciously, shows greater advantages than penicillamine.ConclusionsPenicillamine-bound membrane can be applied as an effective therapeutic intervention for abdominal adhesions with inconsequential side effects.

Synthesis and Characterization of Hydrogel-Based Hyaluronic Acid-Chitosan-Allium sativum Extract for Intraperitoneal Antiadhesion Application

“…Some of them are chemical drugs such as corticosteroids, anticoagulants, antibiotics, fbrinolytic agents, hormones, anti-infammation, and anticoagulants, including aspirin, dexamethasone, and heparin. Barrier liquids such as crystalloids (NaCl and Ringer's lactate) and polymer solutions (N,Ocarboxymethyl Chitosan (NOCC), sodium hyaluronate, and carboxymethyl cellulose (CMC)), although used in large quantities but too fast absorbed [7]. Solid barriers are still challenging to apply because they are difcult to cover all parts of the wound surface and often stick on the surgeon's glove when inserted into the body [8].…”