Administration of Antibiotics during Infancy Promoted the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Watanabe, Jun; Fujiwara, Reiko; Sasajima, Naho; Ito, Susumu; Sonoyama, Kei

doi:10.1271/bbb.90709

Cited by 19 publications

(15 citation statements)

References 45 publications

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“…57 The association of exposure to antibiotics in 3-week-old mice with increased risk of atopies measured by IgE serum levels has been already shown. 58 In addition, Wickens et al have shown the significantly increased risk of positive SPT in children exposed to antibiotics during the first 3 months. 43 Although in our meta-analysis we were limited to test this association in the first 3 months (low number of studies included), we found very similar results for this association in the first 6 months of exposure to antibiotics (data not shown).…”

Section: -56mentioning

confidence: 99%

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Ahmadizar

Vijverberg

Arets

et al. 2017

Allergy

105

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This study systematically reviewed and quantified the relationship between exposure to antibiotics during the first 2 years of life and the risk of allergies/atopies including hay fever, eczema, food allergy, positive skin prick testing (SPT), or elevated allergen-specific serum/plasma immunoglobulin (Ig) E levels later in life.PubMed and Web of Science databases were searched for observational studies published from January 1966 through November 11, 2015. Overall pooled estimates of the odds ratios (ORs) were obtained using fixed or random-effects models. Earlylife exposure to antibiotics appears to be related to an increased risk of allergic symptoms of hay fever, eczema, and food allergy later in life. The summary OR for the risk of hay fever (22 studies Early-life exposure to antibiotics has been related to some later life morbidities such as obesity, arthritis, asthma, and allergies. 6,7 A meta-analysis from 2006 showed a higher risk of asthma among those children exposed to antibiotics in early childhood. 8 However, a more recent meta-analysis from 2011 reported that the association between antibiotics exposure and subsequent development of wheeze/asthma was weak when the analysis was adjusted for reverse causation and confounding by indication. 9Several studies have suggested that early-life exposure to antibiotics is associated with an increased risk of developing allergies and atopies later in life, but results are inconsistent. Therefore, the aim of this study was to conduct a systematic review and meta-analysis to assess and quantify the relationship between early-life exposure to antibiotics and the risk of developing symptoms of hay fever, eczema, food allergy, positive skin prick testing (SPT), or elevated allergen-specific serum/plasma immunoglobulin (Ig) E levels later in life.Abbreviations: CI, confidence interval; HR, hazard ratio; IgE, immunoglobulin E; OR, odds ratio; SPT, skin prick test.

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Section: -56mentioning

confidence: 99%

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Ahmadizar

Vijverberg

Arets

et al. 2017

Allergy

105

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“…Several studies using mice have shown that antibiotic-mediated alterations of the microbiota can enhance allergic disorders. Administration of kanamycin to NC/Nga mice, a mouse model of atopic dermatitis, increased IgE levels and exacerbated allergic symptoms 8 weeks after antibiotic treatment [70]. Antibiotic-treated mice can also be more susceptible to anaphylactic shock following oral administration of a food allergen.…”

Section: Antibiotics Immunity and Diseasementioning

confidence: 99%

Antibiotics, microbiota, and immune defense

Úbeda¹,

Pamer

2012

Trends in Immunology

296

205

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The gastrointestinal tract microbiota contributes to the development and differentiation of the mammalian immune system. The composition of the microbiota affects immune responses and affects susceptibility to infection by intestinal pathogens and development of allergic and inflammatory bowel diseases. Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities and decreases host resistance to antibiotic-resistant microbes. Here, we review recent advances that begin to define the interactions between complex intestinal microbial populations and the mammalian immune system and how this relation is perturbed by antibiotic administration. We further discuss how antibiotic-induced disruption of the microbiota and immune homeostasis can lead to disease and we review strategies to restore immune defenses during antibiotic administration.

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“…9,10 Filaggrin mutation is generally present among approximately 50% of patients with atopic dermatitis compared to 10% in the general population, and cases with filaggrin mutations tend to have an earlier onset. [12][13][14][15][16][17] However, evidence for a role of prenatal antibiotic exposure is scarce, inconsistent and does not take timing of exposure into account. 11 Maternal use of antibiotics in pregnancy influences the maternal microbiome and hence the very early colonization of the child's own microbiome during pregnancy, birth and breast-feeding in early life.…”

Section: Introductionmentioning

confidence: 99%

Prenatal antibiotics and atopic dermatitis among 18‐month‐old children in the Danish National Birth Cohort

Timm

Schlünssen

Olsen

et al. 2017

Clin Experimental Allergy

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Administration of Antibiotics during Infancy Promoted the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

Cited by 19 publications

References 45 publications

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Antibiotics, microbiota, and immune defense

Prenatal antibiotics and atopic dermatitis among 18‐month‐old children in the Danish National Birth Cohort

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