2001
DOI: 10.1016/s0165-0327(00)00307-4
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Administration of antidepressants

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Cited by 19 publications
(1 citation statement)
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“…Evening versus morning administration of duloxetine results in a three-hour delay in absorption and an approximately 33% increase in clearance 39. The plasma and elimination half-lives of duloxetine are approximately 12 hours 40. However, because duloxetine is able to cross the blood–brain barrier, its plasma half-life in the central nervous system (CNS) may be longer than in the peripheral measures typically reported.…”
Section: Pharmacology and Pharmacokineticsmentioning
confidence: 99%
“…Evening versus morning administration of duloxetine results in a three-hour delay in absorption and an approximately 33% increase in clearance 39. The plasma and elimination half-lives of duloxetine are approximately 12 hours 40. However, because duloxetine is able to cross the blood–brain barrier, its plasma half-life in the central nervous system (CNS) may be longer than in the peripheral measures typically reported.…”
Section: Pharmacology and Pharmacokineticsmentioning
confidence: 99%