Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

Kamiya, Akihisa; Machida, Takuji; Hirano, Megumi; Machida, Maiko; Shiga, Saki; Hamaue, Naoya; Hirafuji, Masahiko; Iizuka, Kenji

doi:10.1016/j.jphs.2021.07.007

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…As a biogenic amine derivative, 5-HT is not easy to cross the blood-brain barrier and has different distribution and functions in different parts of the human body. Studies have found that the 5-HT receptor is expressed in human immune cells, including neutrophils, macrophages, and dendritic cells [ 17 ]. The results showed that the serum 5-HT increased significantly in patients with sepsis.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the effective markers of presepsis in the prediction of clinical disease and disease severity, the predictive effect of lactic acid (Lac) combined with cardiac troponin T (cTnT) and 5-hydroxytryptophan (5-HT) on the severity of sepsis in intensive care unit (ICU) patients and its correlation with prognosis is investigated. A total of 85 sepsis patients admitted to the ICU of our hospital from January 2020 to June 2021 are selected to establish the ICU sepsis group, and 72 health examination patients who received physical examination in our hospital during the same period are included in the healthy control group. The experimental results demonstrate that combined detection mode of serum Lac, cTnT, and 5-HT indicators has a high predictive value for the condition of patients with ICU sepsis and those indicators are closely correlated with the prognosis of patients. It suggests that the follow-up clinical monitoring of serum Lac, cTnT, and 5-HT indicators for patients with ICU sepsis can evaluate their condition and improve and optimize the clinical diagnosis and treatment plan effectively.

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Section: Related Workmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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“…The decrease in body weight in the group treated with CP observed in this study may be attributed to anorexia which might suggest that CP has harmful effects on the gastrointestinal tract or appetite center in the hypothalamus [ 25 , 26 ]. Hence, using antioxidants can improve the physical condition and weight gain in animals [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Co-Administration of N-Acetylcysteine and Vitamin E on Cyclophosphamide-Induced Ovarian Toxicity in Female Rats

Raeeszadeh

Hosseini

Amiri

2022

Journal of Toxicology

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Cyclophosphamide is used to treat various types of cancer. However, it can reduce ovarian function and fertility rate. The current study was done to compare the effects of N-acetylcysteine and vitamin E on cyclophosphamide-induced ovarian damage. Thirty-five rats were randomly divided into 5 groups: control (C), cyclophosphamide (CP, 200 mg/kg single dose intraperitoneally), T1 (cyclophosphamide + vitamin E at 200 mg/kg), T2 (cyclophosphamide + 200 mg/kg N-acetylcysteine), and T3 (cyclophosphamide + N-acetylcysteine and vitamin E at 200 mg/kg). The main measurements included total antioxidant capacity (TAC), glutathione peroxidase (GPx), malondialdehyde (MDA), interleukin 8 (IL-8), tumor necrosis factor-α (TNFα), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estrogen (ES). Except for the C and T3 groups, the other groups lost weight. A significantly lower concentration of MDA was observed in the T3 group. However, TAC was substantially increased compared to the other groups. The level of GPx in the S group was significantly reduced compared to all groups. Proinflammatory markers (IL-8 and TNFα) reached their lowest serum level in the T3 group, with a statistically significant difference compared to that of the S group. In addition, there were no significant differences in the means of primary, secondary, and graph and atretic follicles between the T3 and C group. On the other hand, a decrease in FSH and LH was observed while an increase in ES was seen in the T3 group compared to the S group. This study revealed that N-acetylcysteine and vitamin E coadministration could significantly decrease the side effects of cyclophosphamide, especially in ovarian tissue.

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“…Nausea and vomiting are common side effects of cancer chemotherapy, and they can linger for several days. Cyclophosphamide is a strong emetogenic stimulant that causes severe nausea and vomiting in the majority of patients [24]. In the current study, we investigated the anti‐emetic effect of C. sativa in a pica rat model established by intraperitoneal injection of cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors

Elgohary

Salama

Omara

2022

Fundamemntal Clinical Pharma

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Cyclophosphamide is an anticancer and immunosuppressive agent used in the treatment of various malignancies but causing gastrointestinal distress. Cannabis sativa and its derivatives have been used for the treatment of human gastrointestinal disorders. A purpose of this study was to investigate the effect of C. sativa on nausea induced by cyclophosphamide in rats. The rats were divided into four groups (eight animals per group): Group 1: Normal control (saline i.p.). Group 2: Rats received cyclophosphamide (200 mg/kg i.p.) 3 consecutive days. Group 3 and 4: Rats received cyclophosphamide (200 mg/kg i.p.) across Days 1–7, and C. sativa (20 and 40 mg/kg s.c.) was administered on cyclophosphamide days 4–7. We examined intake of kaolin, normal food and changes in body weight, as an indicator of the emetic stimulus. Oxidative stress markers, antioxidant enzymes status, serotonin (5‐HT), dopamine, noradrenaline and CB1R levels were evaluated in the intestinal homogenate. Moreover, histopathological study was performed. Results showed that C. sativa ameliorates cyclophosphamide‐induced emesis by increasing in body weight and normal diet intake with a decrease in kaolin diet intake after 7 days. Moreover, C. sativa significantly decreases (serotonin) 5‐HT, dopamine and noradrenaline, as well as decreasing oxidative stress and inflammation. Administration of C. sativa significantly increased the expression of CB1R in intestinal homogenate. Treatment with C. sativa also improved the histological feature of an intestinal tissue. These results suggested that C. sativa possess antiemetic, antioxidant and anti‐inflammatory effects in chemotherapy‐induced nausea in rats by activating CB1R.

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Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

Cited by 10 publications

References 29 publications

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Impact of Co-Administration of N-Acetylcysteine and Vitamin E on Cyclophosphamide-Induced Ovarian Toxicity in Female Rats

Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors

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