Administration of Exogenous Hormones and the Implications for Cigarette Smoking-Related Behaviors

Allen, Alicia M.; Mallahan, Stephanie; Ortega, Alexis; Miller, Heather; Saleh, Ahlam; Bonny, Andrea E.

doi:10.1007/s11920-020-01197-6

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…The use of other types of exogenous hormones such as natural progesterone for treating menopausal symptoms or preventing preterm birth may also be considered for smoking cessation. 37 Intervention implementation considerations should be made regarding delivery mode and education on anticipated adverse effects (and lack thereof).…”

Section: Discussionmentioning

confidence: 99%

“…We selected these options based on currently available forms of HC that are less invasive forms of contraceptive as compared with the intrauterine device or implant. 37 In addition, because exogenous administration of ethinyl estradiol is contraindicated in women over the age of 35 and those who smoke while progestin is safe, 45 we also wanted to assess the perceptions of safety for the differing hormones. For each HC type participants indicated they were unwilling to use, an additional short-answer, open-ended question was prompted to ask why they were unwilling to use that type.…”

Section: Methodsmentioning

confidence: 99%

“…While these data are still emerging, one theory is that because the use of HCs blocks ovulation—resulting in the reduction of the ovarian hormonal fluctuations that occur with the natural menstrual cycle and reduction in estrogen levels 36 —there may be a decreased smoking relapse risk. 37 Despite these promising observations, it is important to note that ethinyl estradiol (the synthetic form of estrogen commonly used in combination oral contraceptives) is contraindicated in women who smoke or those over the age of 35 due to an increase in cardiovascular issues. 38 , 39…”

Section: Introductionmentioning

confidence: 99%

“…In addition, HCs are used off-label to treat a variety of health issues ( e.g ., acne, endometriosis), though they have not yet been used for smoking cessation. 37 , 43 Therefore, we sought to assess the willingness of reproductive-age women who smoke to use various types of HCs, including synthetic exogenous hormones ( i.e ., ethinyl estradiol, progestin) and administrations ( i.e ., injectable, oral, patch, vaginal insert), for smoking cessation.…”

Section: Introductionmentioning

confidence: 99%

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Acceptability of Hormonal Contraceptives as a Smoking Cessation Aid for Women of Reproductive Age: A Web-Based Cross-Sectional Survey

Werts-Pelter,

Choi,

Mallahan

et al. 2024

Women's Health Reports

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Introduction: Cigarette smoking is the most common cause of preventable cancers and other premature morbidity and mortality. Modifying hormonal patterns using hormonal contraceptives (HCs) may lead to improved smoking cessation outcomes in women, though the acceptability of this is unknown. Therefore, we explored the willingness of reproductive-age women who smoke to use HC for cessation. Methods: A cross-sectional online survey was conducted with a convenience sample of reproductive-age women living in the United States who self-reported smoking combustible cigarettes. Questions covered smoking history, previous HC use, and willingness to use various HC methods ( i.e ., injectable, oral, patch, vaginal insert) for cessation. Chi-squared tests and logistic regression were conducted using StataBE 17.1. Results: Of 358 eligible respondents, n = 312 (86.9%) reported previous HC use. Average age of those with HC use history was 32.1 ± 6.1 years compared with 27.8 ± 6.7 years for those without history of HC use ( p = 0.001). Of respondents who reported previous HC use, 75.6% reported willingness to use HCs, compared with 60.9% of those without a history of HC use. Overall, willingness to use various types of HC ranged from 22.6% for the vaginal insert to 59.2% willing to use an oral contraceptive. Discussion: These observations indicate that most women who smoke cigarettes are willing to use HC for a smoking cessation aid, especially if they have a history of HC use and with an oral form of HC. To improve the rate of smoking cessation for women of reproductive age, future interventions should explore how to incorporate HC for cessation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acceptability of Hormonal Contraceptives as a Smoking Cessation Aid for Women of Reproductive Age: A Web-Based Cross-Sectional Survey

Werts-Pelter,

Choi,

Mallahan

et al. 2024

Women's Health Reports

Self Cite

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“…One study discovered that exogenous progesterone increased the odds of quitting in females nearly 3-fold and averaged 6 more days before relapse ( 28 ). The proposition of exogenous progesterone, either as an adjunctive or stand-alone therapy for smoking cessation has been put forward ( 29 ). Further epidemiological studies are required to better understand the correlation between OCs and tobacco use.…”

Section: Discussionmentioning

confidence: 99%

Smoking-diseases correlation database: comprehensive analysis of the correlation between smoking and 422 diseases based on NHANES 2013–2018

Chen,

Wang,

Tian

et al. 2024

Front. Public Health

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BackgroundSmoking is a risk factor for a wide range of diseases. Previous research has confirmed over 30 Smoking-Associated Diseases in diverse systems. There is limited research exploring the correlation among multiple diseases, with an absence of comprehensive investigations. Few studies concentrate on diseases exhibiting a negative correlation with smoking, wherein smokers demonstrate a lower prevalence.ObjectiveThis study aimed to detect the correlation between smoking and other diseases using data from National Health and Nutrition Examination Surveys (NHANES) and construct a Smoking-Diseases Correlation Database (SDCD). The second aim is to obtain an extensive screening test for diseases that may be linked to smoking.Methods39,126 subjects’ data from the NHANES 2013–2018 dataset were extracted. The baseline information, difference in blood routine and blood chemistry indicators between smokers and non-smokers, and diseases’ correlation with smoking in four different models were analyzed by R. The data and statistics were aggregated into an online SDCD.ResultsOur study reported 46 Smoking-Associated Diseases (SAD), including 29 Smoking Positively Associated Diseases (SPAD) and 17 Smoking Negatively Associated Diseases (SNAD). The SDCD of 422 diseases was constructed and can be accessed at https://chatgptmodel.shinyapps.io/sdcd/.ConclusionOur findings revealed 46 SADs including 29 SPADs and 17 SNADs. We aggregated the statistics and developed online SDCD, advancing our understanding of the correlation between smoking and diseases.

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A protocol for modifying progesterone to increase postpartum cigarette smoking abstinence and reduce secondhand smoke exposure in infants

Abdelwahab,

Allen,

Harrison

et al. 2024

Contemporary Clinical Trials Communications

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Administration of Exogenous Hormones and the Implications for Cigarette Smoking-Related Behaviors

Cited by 5 publications

References 34 publications

Acceptability of Hormonal Contraceptives as a Smoking Cessation Aid for Women of Reproductive Age: A Web-Based Cross-Sectional Survey

Acceptability of Hormonal Contraceptives as a Smoking Cessation Aid for Women of Reproductive Age: A Web-Based Cross-Sectional Survey

Smoking-diseases correlation database: comprehensive analysis of the correlation between smoking and 422 diseases based on NHANES 2013–2018

A protocol for modifying progesterone to increase postpartum cigarette smoking abstinence and reduce secondhand smoke exposure in infants

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