Administration of GABAB receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference

Voigt, Robin M.; Herrold, Amy A.; Riddle, Jennifer L.; Napier, T. Celeste

doi:10.1016/j.bbr.2010.08.034

Cited by 34 publications

(26 citation statements)

References 47 publications

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“…Alternatively, evidence in animals has consistently shown that cocaine and amphetamine inhibit GABA transmission in the striatum (Centonze et al, 2002), and enhancement of GABAergic activity reduces cocaine and methamphetamine addiction (Hip et al, 2007; Voigt et al, 2011). Since a majority of the striatal CB 1 receptors are located presynaptically on inhibitory GABAergic terminals in a position to modulate neurotransmitter release (Julian et al, 2003), a functional interaction between CB 1 and GABAergic transmission in striatum cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

Qiu

Zhang

et al. 2014

Drug and Alcohol Dependence

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Background Cannabinoid CB1 receptors play an essential role in drug addiction. Given the side effect profiles of orthosteric CB1 antagonism, new strategies have been attempted to modulate this target, such as CB1 receptor allosteric modulation. However, the effect of CB1 allosteric modulation in drug addiction is unknown. The present study examined the effects of the CB1 receptor allosteric modulator ORG27569 on the reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Methods Rats were trained to self-administer 0.75 mg/kg cocaine or 0.05 mg/kg methamphetamine in 2-hr daily sessions for 14 days which was followed by 7 days of extinction sessions in which rats responded on the levers with no programmed consequences. On reinstatement test sessions, rats were administered ORG27569 (1.0, 3.2, 5.6 mg/kg, i.p.) or SR141716A (3.2 mg/kg, i.p.) 10 min prior to re-exposure to cocaine- or methamphetamine-paired cues or a priming injection of cocaine (10 mg/kg, i.p.) or methamphetamine (1 mg/kg, i.p.). Results Both cues and a priming injection of cocaine or methamphetamine significantly reinstated the extinguished active lever responding. Pretreatment with ORG27569 resulted in a dose-related attenuation of both cue- and drug-induced reinstatement of cocaine- and methamphetamine-seeking behavior. SR141716A also exhibited similar inhibitory action on reinstatement of drug-seeking behavior. Conclusion Negative allosteric modulation of CB1 receptors can produce similar functional antagonism as orthosteric CB1 receptor antagonists on reinstatement of drug-seeking behavior. Thus, ORG27569 or other negative allosteric modulators deserve further study as potentially effective pharmacotherapy for drug addiction.

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Section: Discussionmentioning

confidence: 99%

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

Qiu

Zhang

et al. 2014

Drug and Alcohol Dependence

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“…We have used both biased and unbiased CPP procedures in our studies with rats (Shen et al, 2006; Voigt et al, 2011b; Herrold et al, 2012) and humans (Childs and de Wit, 2009; 2011). Regarding our human studies, we first used an unbiased procedure (Childs and de Wit, 2009), assigning subjects to room-drug conditions without considering initial preferences.…”

Section: Methodological Considerations For Cpp Proceduresmentioning

confidence: 99%

“…see, Graves et al, 2012a; Herrold et al, 2009; 2012; Herzig and Schmidt, 2004; Herzig et al, 2005; Kang et al, 2008; Vidal-Infer et al, 2012; Voigt et al, 2011b; Ye et al, 2004). Testing potential therapies in the laboratory at the time of expression of conditioned responses may be more clinically relevant as treatment for human addiction processes have to be effective against conditioning that has already taken place (Brandon et al, 2011; Fox et al, 2012; Franklin et al, 2011; Langleben et al, 2012; Mogg et al, 2012).…”

Section: Conditioned Drug Effectsmentioning

confidence: 99%

“…To support this concept, in the following sections, we overview laboratory CPP studies of treatments that now have moved to the clinic for reducing relapse. It is important to note that only a relatively small number of studies with rodents have targeted the expression of CPP to identify new treatments for drug abuse (Graves et al, 2012a; Herrold et al, 2009; 2012; Herzig and Schmidt, 2004; Herzig et al, 2005; Kang et al, 2008; Vidal-Infer et al, 2012; Voigt et al, 2011b; Ye et al, 2004). Of these, some evaluated potential treatments that now are FDA-approved addiction medications, and others have use compounds approved for other CNS pathologies that may be repurposed for addiction therapy.…”

Section: Utility Of Cpp In Medication Development For Addictionmentioning

confidence: 99%

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Using conditioned place preference to identify relapse prevention medications

Napier

Herrold

Wit

2013

Neuroscience & Biobehavioral Reviews

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Stimuli, including contexts, which predict the availability or onset of a drug effect, can acquire conditioned incentive motivational properties. These conditioned properties endure after withdrawal, and can promote drug-seeking which may result in relapse. Conditioned place preference (CPP) assesses the associations between drugs and the context in which they are experienced. Here, we review the potential utility of CPP procedures in rodents and humans to evaluate medications that target conditioned drug-seeking responses. We discuss the translational potential of the CPP procedure from rodents to humans, and review findings with FDA-approved treatments that support the use of CPP to develop relapse-reduction medications. We also discuss challenges and methodological questions in applying the CPP procedure to this purpose. We argue that an efficient and valid CPP procedure in humans may reduce the burden of full clinical trials with drug-abusing patients that are currently required for testing promising treatments.

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“…Furthermore, receptor desensitization and down regulation that occur with chronic agonist administration are not observed with PAMs (Gjoni and Urwyler 2008). Similar to baclofen, GABA B R PAMs (CGP7930 and GS39783) reduce the maintenance of meth-induced CPP (Voigt et al 2011b), cocaine self-administration (Filip et al 2007;Halbout et al 2011;Smith et al 2004), cocaine- and cue-induced reinstatement of cocaine-seeking (Filip and Frankowska 2007), nicotine self-administration, and counteract nicotine-induced enhancement of brain reward function (Paterson et al 2008). Attenuation of stimulant-induced behaviors is also observed with L-type Ca 2+ channel blockers which inhibit the expression of nicotine- (Biala 2003), meth-, and cocaine- (Suzuki et al 1992) induced CPP, cocaine-induced behavioral sensitization (Martin-Iverson and Reimer 1994), the acquisition and consolidation of nicotine-induced cognitive effects (Biala et al 2013), and attenuate drug-primed reinstatement of nicotine self-administration (Biala and Budzynska 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats

2013

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Rationale Fendiline is a GABAB receptor positive allosteric modulator and L-type Ca2+ channel blocker that is safe for human use. Based on these pharmacological properties, fendiline may be useful to disrupt associative memories that can drive relapse to drug use in drug-addicted individuals. Objective The current study evaluated the potential of fendiline to inhibit the maintenance and expression of learned associations between methamphetamine (meth) and an environmental context using conditioned place preference (CPP) in rats, to model for the associative learning that occurs during drug abuse by humans. Methods Following meth conditioning (1mg/kg), fendiline (5mg/kg) was administered at various post-conditioning times to ascertain if there was a temporal window during which fendiline would be effective. Results Two once-daily injections of fendiline did not influence the maintenance of CPP regardless of the post-conditioning treatment time while 10 once-daily fendiline treatments inhibited CPP maintenance (p<0.05). Fendiline administered immediately prior to the CPP test inhibited expression of meth-induced CPP in rats with a fendiline treatment history of 10 once-daily injections (p<0.05) or those that received two injections that corresponded to the last two days of the 10 day treatment (p<0.05). Fendiline did not produce preference or aversion on its own, nor did it alter motivated motor behavior. Conclusion Maintenance and expression of meth CPP is mitigated by repeated fendiline treatments when administered during the days that precede CPP testing. Reduction in the significance of meth-associated cues can reduce relapse; therefore, fendiline may be of value for addiction therapy in abstinent, meth-addicted humans.

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Administration of GABAB receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference

Cited by 34 publications

References 47 publications

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

Using conditioned place preference to identify relapse prevention medications

Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats

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