Administration of Silver Nanoparticles in Diabetes Mellitus:  A Systematic Review and Meta-analysis on Animal Studies

Torabian, Farnaz; Rezayat, Arash Akhavan; Nour, Mohammad Ghasemi; Ghorbanzadeh, Atefeh; Najafi, Sara; Sahebkar, Amirhossein; Sabouri, Zahra; Darroudi, Majid

doi:10.1007/s12011-021-02776-1

Cited by 23 publications

(11 citation statements)

References 43 publications

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“…Silver nanoparticles prepared using the environmentally friendly garlic plant protect sperm by increasing the oxidative activity in the immune system, thus preventing reactive oxygen species from lipid peroxidation stimulation responsible for subsequent sperm damage. Our result clearly indicates the important role of silver nanoparticles in various medical applications 53 , 54 .…”

Section: Resultssupporting

confidence: 62%

Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin

Ali

Ahmed

Al-Ahmed

2023

Sci Rep

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The present study used physics to synthesize silver nanoparticles using aqueous extract of fresh garlic as reducing and as a stabilizing agent silver nitrate solution. This method has proven to be environmentally friendly and safe for the synthesis of stable silver nanoparticles. The acquisition of silver nanoparticles was confirmed by optical detection, that is, by changing the color of the liquid to transparent orange and then blackish brown. Then, the characterization was confirmed using other assays. In this study, it was found that the absorption peak of silver nanoparticles was at a wavelength of 420 nm and the particle size ranged between [50–350] nm. The surface roughness of silver oxide/silver nanoparticles was 9.32 nm with an average square roughness of 21.19 nm, and the energy dispersive spectra showed that the absorption peak was in the region of 3 keV, indicating that the nanoparticles contained crystalline silver. In this study, the stability of the silver nanoparticles was good, as ZP reached (− 19.5). The results confirm that the conductivity increases with the increase in frequency due to the high energy of the photons, which causes the electrons to vibrate in the energy levels and thus increase the energy in the mitochondria and increase the movement of sperm in the Diabetic mice treated with doses of silver nanoparticles. The toxic effect of silver nanoparticles has been evaluated in other studies, in addition to evaluating antioxidants, antifungals, treating cancer cells, regulating cholesterol levels, the effect of these nanoparticles on sex cells in pregnant female mice, heart tension, and many other tests. In this study, the activities and efficacy of silver nanoparticles on sperms were determined in male mice with diabetes caused by STZ, and the treatment period was long (35 days) so that the evaluation period was a complete life cycle of male sex cells and within a long period of time and at an average nano size. This has not been studied in other previous studies. The results indicate that the biosynthesis of silver nanoparticles using garlic plant led to positive results on sperm treatments by contributing to an increase in the number of sperm with reactivation and a decrease in abnormalities in addition to a decrease in mortality due to diabetes. This is evidence that the synthesis of silver nanoparticles using garlic plant size (50–350 nm) can treat impotence and be used in the future in the treatment of many diseases without side effects.

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Section: Resultssupporting

confidence: 62%

Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin

Ali

Ahmed

Al-Ahmed

2023

Sci Rep

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“…Te positively charged surface, ligand replacement ability, and oxidative dissolution capabilities of Ag-NPs facilitate their binding to the negatively charged bacterial cell-wall, resulting in an enhanced bactericidal efect [22,23]. Because of those advantageous features, Ag-NPs have emphasized in various biomedical [24][25][26] and biological applications including antibacterial, anticancer [27,28], antiinfammatory, antiangiogenic [29], antifungal, antiviral agents [30,31] and in several other industrial and household applications, such as cosmetic products, medical device coating, freeze coating, optical sensor developments [32], diagnostic device development [33][34][35][36], paint industry, food industry, socks, clothing, and disinfectant [37,38]. Following those applications, recently, many researchers of Bangladesh have already utilized imported nanomaterials from the commercial sources [37].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis and Application of Ag-NPs for Controlling Antibiotic-ResistantPseudomonas spp. and Bacillus spp. in a Poultry Farm Environment

Rahman

Rasid

Ali

et al. 2023

Journal of Nanotechnology

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This study synthesized silver nanoparticles (Ag-NPs) using silver nitrate (AgNO3) as the ion source and sodium tripolyphosphate (STPP) as reducing as well as capping agents. The synthesized Ag-NPs were confirmed initially using Ag-NPs specific λmax at 410 nm with UV-Vis spectrophotometry and homogenously distributed, 100–300 nm size, and round-shaped particles were realized through atomic force microscopy (AFM) and transmission electron microscopy (TEM) image analysis. The various reaction condition-based studies revealed 0.01 M AgNO3 yields maximum particle after 4 h reduction with 1% STPP. Bacillus spp. (n = 23/90) and Pseudomonas spp. (n = 26/90) were isolated from three different poultry farms for evaluating the antibacterial activity of Ag-NPs. Among the PCR confirmed isolates, 52% (12/23) Bacillus spp. were resistant to ten antibiotics and 65% (17/26) Pseudomonas spp. were resistant to eleven antibiotics. The representative resistant isolates were subjected to antibacterial evaluation of synthesized Ag-NPs following the well diffusion method, revealing the maximum sensitive zone of inhibition 19 ± 0.2 mm against Bacillus spp. and 17 ± 0.38 mm against Pseudomonas spp. The minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) of Ag-NPs were 2.1 μg/ml and 8.4 μg/ml, respectively, for broad-spectrum application. Finally, the biocompatibility was determined by observing the viability of Ag-NP-treated BHK-21 cell through trypan blue-based exclusion assay revealing nonsignificant decreased of cell viability ≤2MIC doses. Thus, the synthesized Ag-NPs were proven as biocompatible and sensitive to both Gram-positive and Gram-negative bacteria of the poultry farm environmental samples.

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“…Acorde con Tavakoli et al (2020) la capacidad de las NPsAg para infiltrarse en los tejidos ha generado resistencia contra su eliminación en la sangre y ha provocado la agregación de partículas en los tejidos utilizables. Debido a los informes de los efectos peligrosos de las NPsAg, se considera necesario investigar histopatológicamente el hígado y el riñón de los pollos de engorda alimentados con NPsAg; además, en los últimos años se ha considerado usar NPsAg para aumentar el nivel de insulina de algunos animales diabéticos, lo que ha resultado en una disminución de la condición de hiperglucemia, debido a eso puede ser factible emplear estas NPs en el tratamiento de diabetes mellitus en animales (Torabian et al, 2022).…”

Section: Uso De Nanopartículas Diversas En Animales De Interés Alimen...unclassified

Beneficios Potenciales de la Nanotecnología Para una Producción Animal Más Eficiente

Méndez-Argüello¹,

Lira-Saldívar²

2023

JBNS

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Administration of Silver Nanoparticles in Diabetes Mellitus: A Systematic Review and Meta-analysis on Animal Studies

Cited by 23 publications

References 43 publications

Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin

Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin

Facile Synthesis and Application of Ag-NPs for Controlling Antibiotic-ResistantPseudomonas spp. and Bacillus spp. in a Poultry Farm Environment

Beneficios Potenciales de la Nanotecnología Para una Producción Animal Más Eficiente

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