Administration of skin care regimens containing β‐glucan for skin recovery after fractional laser therapy: A split‐face, double‐blinded, vehicle‐controlled study

Abstract

Background: Laser therapies have brought dawn to refractory skin diseases, but also were accompanied by postlaser inflammation and skin barrier dysfunction. To recover skin function quickly, the research and development of active ingredients including β-glucan for postlaser repair have attracted much attention. Aims: To evaluate the efficacy and tolerance of skin care regimens containing β-glucan (Dermdoc®;Songyang Biotech) in repairing postlaser inflammation and skin barrier dysfunction after fractional laser therapy. Methods: A total of 20 patients with facial atrophic acne scars who accepted fractional laser therapy were recruited: 10 patients treated with ablative fractional CO2 laser and 10 patients treated with 1565nm nonablative fractional laser. Using the method of split-face vehicle-control study, the left half of the face was served as the treatment side and accepted skin care regimens, and the right half was control side accepted vehicle. Noninvasive bioinstrumentation of skin hydration index, transepidermal water loss (TEWL), and hemoglobin index (E value) was detected in the study.Standard digital photographs were taken at each visit. The skin tolerance and adverse effect were also evaluated by subject questionnaire.Results: Compared with the control side, the Hemoglobin index (E value) of the treatment side was improved more significantly on the 7th day (P < .05). The skin hydration index of the treatment side was better than that of the control side on the 7th and 14th day (P < .05). After treatment, the TEWL of the treatment side on the 7th day was statistically significantly lower than that of the control side (P < .05). In the subject self-assessment questionnaires, 63.2% thought the repair effect of β-glucan regimens was better than that of vehicle. The skin care regimens were well tolerated without obvious side reactions. Conclusion:The skin care regimens containing β-glucan may play a positive role in accelerating the recovery of skin inflammation and barrier function after fractional laser therapy.

Artificial saliva plus beta-glucan for treatment of xerostomia in older adults: The clinical study of effectiveness and salivary total antioxidant capacity levels

“…Cao et al discovered that β-glucan-containing skin care regimens may help heal skin inflammation and barrier function following fractional laser therapy. 20 According to the study of Natakankitkul et al, β-glucan extract from yeast waste has positive cosmeceutical qualities, such as moisture retention and skin regeneration. 21 The amount of saliva that is retained on and moistens the oral surface appears to be a critical factor in oral pain, and its decrease is related to a worsening sensation of dryness.…”

An important polysaccharide from fermentum

“…Fermentum β-polysaccharide is favoured by many cosmetic manufacturers for its ability to help reduce skin irritation, effectively reduce wrinkles, improve skin hydration and smoothness, promote scar healing and regeneration, etc. Fermentum β-polysaccharide has a spiral structure that is extremely insoluble in water, so the Fermentum β-polysaccharide that was first used in cosmetics was a water-insoluble solid particle, a structure suitable for use in wound healing ( Cao et al, 2021 ). In the human skin, there are dendritic cells called Langerhans cells, which are mainly located in the upper-middle layer of the epidermis.…”

Safety and efficacy of human platelet extract in skin recovery after fractional CO2 laser resurfacing of the face: A randomized, controlled, evaluator‐blinded pilot study

“…Ideally, topical dressings following ablative laser procedures should improve and optimize the wound healing microenvironment 7 . Studies have been conducted to evaluate application of many products after laser resurfacing, including platelet‐rich plasma (PRP), 8 mesenchymal stem cell media, 9,10 oxygen emulsions, 11 fusidic acid cream, 12 Cryptomphalus aspersa , 13 and skin care regimens containing β‐glucan 14,15 . Posttreatment topical steroids have also been shown to reduce downtime but remains controversial as they may increase other side effects and potentially impact long‐term benefits of thermolysis 6,15 .…”

“…7 Studies have been conducted to evaluate application of many products after laser resurfacing, including platelet-rich plasma (PRP), 8 mesenchymal stem cell media, 9,10 oxygen emulsions, 11 fusidic acid cream, 12 Cryptomphalus aspersa, 13 and skin care regimens containing β-glucan. 14,15 Posttreatment topical steroids have also been shown to reduce downtime but remains controversial as they may increase other side effects and potentially impact long-term benefits of thermolysis. 6,15 Recovery agents such as Aquaphor, Vaseline, and Vanicream Moisturizing Ointment are commonly used in the early post-laser recovery period to create an occlusive barrier to hold moisture and provide protection to the skin from pollutants in the air as the skin heals.…”