Administration of tibolone decreases 24h heart rate but not blood pressure of post-menopausal women

Effects of menopause and tibolone on different cardiovascular biomarkers in healthy women

“…In the present study, we observed a significant decrease in both systolic and diastolic pressure after treatment with tibolone, which restored blood pressure to levels similar to those found in premenopausal women. Conversely, different other data indicate a neutral effect or only a trend to lower values of both systolic and diastolic pressure after tibolone treatment [2,[9][10][11][12]. To note, hypertension represents the single most important risk factor in elderly women, especially when associated with insulin resistance or diabetes [13].…”

Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women: lack of effect of soy supplementation

“…The women had used tibolone for at least 3 months (mean of 21 months) and this exposure time should be long enough for tibolone to trigger effects on cardiovascular risk factors associated with its use 13,14 . Although estrogen therapy alone may reduce blood pressure 19 , no such effect has been reported with tibolone 20 . In order to define equol production capability in our tibolone-treated women, we used a 1-week soy challenge and classified equol production as at least a four-fold elevation in baseline serum equol level.…”

Influencia de la tibolona en la función sexual y seguridad cardiovascular en la mujer posmenopáusica

“…No existen ensayos clínicos controlados aleatorizados que demuestren efectos perjudiciales de la tibolona a nivel cardiovascular; pero se han descubierto efectos cardiovasculares neutros (45), incluso potencialmente beneficiosos (46,47). En el perfil lipídico produce disminución significativa en las concentraciones plasmáticas de colesterol total (CT), triglicéridos, colesterol unido a lipoproteínas de alta densidad (C-HDL), colesterol unido a lipoproteínas de baja densidad (C-LDL), lipoproteína (a) (Lp (a)) y apoproteína B (Apo B) (48,49,50).…”